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Table of Contents: July 2011

Issue Image

Embryos on the left and right have arrested at the 2-fold stage of embryogenesis due to developmental defects caused by the sperm-delivered toxin, PEEL-1. The hatched larva in the center of the image has developed normally because this animal has inherited a single copy of the antidote gene, zeel-1. (See Seidel et al., e1001115.)

Essay

Darwin in Mind: New Opportunities for Evolutionary Psychology

Johan J. Bolhuis, Gillian R. Brown, Robert C. Richardson, Kevin N. Laland

Perspectives

The Reality of Pervasive Transcription

Michael B. Clark, Paulo P. Amaral, Felix J. Schlesinger, Marcel E. Dinger, Ryan J. Taft, John L. Rinn, Chris P. Ponting, Peter F. Stadler, Kevin V. Morris, Antonin Morillon, Joel S. Rozowsky, Mark B. Gerstein, Claes Wahlestedt, Yoshihide Hayashizaki, Piero Carninci, Thomas R. Gingeras, John S. Mattick

Response to “The Reality of Pervasive Transcription”

Harm van Bakel, Corey Nislow, Benjamin J. Blencowe, Timothy R. Hughes

Historical and Philosophical Perspectives

Obituary

Primers

Nothing Iffy about HIF in the Hypothalamus

Sam Virtue, Antonio Vidal-Puig

Community Page

Modernizing Reference Genome Assemblies

Deanna M. Church, Valerie A. Schneider, Tina Graves, Katherine Auger, Fiona Cunningham, Nathan Bouk, Hsiu-Chuan Chen, Richa Agarwala, William M. McLaren, Graham R.S. Ritchie, Derek Albracht, Milinn Kremitzki, Susan Rock, Holland Kotkiewicz, Colin Kremitzki, Aye Wollam, Lee Trani, Lucinda Fulton, Robert Fulton, Lucy Matthews, Siobhan Whitehead, Will Chow, James Torrance, Matthew Dunn, Glenn Harden, Glen Threadgold, Jonathan Wood, Joanna Collins, Paul Heath, Guy Griffiths, Sarah Pelan, Darren Grafham, Evan E. Eichler, George Weinstock, Elaine R. Mardis, Richard K. Wilson, Kerstin Howe, Paul Flicek, Tim Hubbard

Research Articles

Gene Gain and Loss during Evolution of Obligate Parasitism in the White Rust Pathogen of Arabidopsis thaliana

Eric Kemen, Anastasia Gardiner, Torsten Schultz-Larsen, Ariane C. Kemen, Alexi L. Balmuth, Alexandre Robert-Seilaniantz, Kate Bailey, Eric Holub, David J. Studholme, Dan MacLean, Jonathan D. G. Jones

A Novel Sperm-Delivered Toxin Causes Late-Stage Embryo Lethality and Transmission Ratio Distortion in C. elegans

Hannah S. Seidel, Michael Ailion, Jialing Li, Alexander van Oudenaarden, Matthew V. Rockman, Leonid Kruglyak

Generation of Healthy Mice from Gene-Corrected Disease-Specific Induced Pluripotent Stem Cells

Guangming Wu, Na Liu, Ina Rittelmeyer, Amar Deep Sharma, Malte Sgodda, Holm Zaehres, Martina Bleidißel, Boris Greber, Luca Gentile, Dong Wook Han, Cornelia Rudolph, Doris Steinemann, Axel Schambach, Michael Ott, Hans R. Schöler, Tobias Cantz

Synaptic Transmission from Horizontal Cells to Cones Is Impaired by Loss of Connexin Hemichannels

Lauw J. Klaassen, Ziyi Sun, Marvin N. Steijaert, Petra Bolte, Iris Fahrenfort, Trijntje Sjoerdsma, Jan Klooster, Yvonne Claassen, Colleen R. Shields, Huub M. M. Ten Eikelder, Ulrike Janssen-Bienhold, Georg Zoidl, Douglas G. McMahon, Maarten Kamermans

Formation of the Long Range Dpp Morphogen Gradient

Gerald Schwank, Sascha Dalessi, Schu-Fee Yang, Ryohei Yagi, Aitana Morton de Lachapelle, Markus Affolter, Sven Bergmann, Konrad Basler

Coupled Evolution of Transcription and mRNA Degradation

Mally Dori-Bachash, Efrat Shema, Itay Tirosh

Defining the Specificity of Cotranslationally Acting Chaperones by Systematic Analysis of mRNAs Associated with Ribosome-Nascent Chain Complexes

Marta del Alamo, Daniel J. Hogan, Sebastian Pechmann, Veronique Albanese, Patrick O. Brown, Judith Frydman

The Cryo-EM Structure of a Complete 30S Translation Initiation Complex from Escherichia coli

Patricia Julián, Pohl Milon, Xabier Agirrezabala, Gorka Lasso, David Gil, Marina V. Rodnina, Mikel Valle