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Table of Contents: November 2010

COVER

Microtubules regulate cell geometry.

Image Credit: Remigio Picone, Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London
Issue Image

The regulation of cell shape and size is important for a wide variety of biological processes. A study conducted at University College London (see Picone et al., e1000542) reveals that microtubules (shown in green) impose unexpected limits on cell geometry, which enable cells to regulate their length. Since cells are the building blocks and architects of tissue morphogenesis, such intrinsically defined limits may be important for development and homeostasis in multicellular eukaryotes.

Editorial

Synopses

Essay

Perspective

“Interactive Technology Assessment” and Beyond: the Field Trial of Genetically Modified Grapevines at INRA-Colmar

Olivier Lemaire, Anne Moneyron, Jean E. Masson , The Local Monitoring Committee

Book Review/Science in the Media

Primer

Epigenetics of Royalty

Alexandra Chittka, Lars Chittka

Research Articles

Ancient DNA from European Early Neolithic Farmers Reveals Their Near Eastern Affinities

Wolfgang Haak, Oleg Balanovsky, Juan J. Sanchez, Sergey Koshel, Valery Zaporozhchenko, Christina J. Adler, Clio S. I. Der Sarkissian, Guido Brandt, Carolin Schwarz, Nicole Nicklisch, Veit Dresely, Barbara Fritsch, Elena Balanovska, Richard Villems, Harald Meller, Kurt W. Alt, Alan Cooper , the Genographic Consortium

Evolutionary Relationships of Wild Hominids Recapitulated by Gut Microbial Communities

Howard Ochman, Michael Worobey, Chih-Horng Kuo, Jean-Bosco N. Ndjango, Martine Peeters, Beatrice H. Hahn, Philip Hugenholtz

Pheromonal and Behavioral Cues Trigger Male-to-Female Aggression in Drosophila

María de la Paz Fernández, Yick-Bun Chan, Joanne Y. Yew, Jean-Christophe Billeter, Klaus Dreisewerd, Joel D. Levine, Edward A. Kravitz

The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis

Tokameh Mahmoudi, Sylvia F. Boj, Pantelis Hatzis, Vivian S. W. Li, Nadia Taouatas, Robert G. J. Vries, Hans Teunissen, Harry Begthel, Jeroen Korving, Shabaz Mohammed, Albert J. R. Heck, Hans Clevers

A Post-Burst Afterdepolarization Is Mediated by Group I Metabotropic Glutamate Receptor-Dependent Upregulation of Cav2.3 R-Type Calcium Channels in CA1 Pyramidal Neurons

Jin-Yong Park, Stefan Remy, Juan Varela, Donald C. Cooper, Sungkwon Chung, Ho-Won Kang, Jung-Ha Lee, Nelson Spruston

Microglial Interactions with Synapses Are Modulated by Visual Experience

Marie-Ève Tremblay, Rebecca L. Lowery, Ania K. Majewska

Quantitative Control of Organ Shape by Combinatorial Gene Activity

Min-Long Cui, Lucy Copsey, Amelia A. Green, J. Andrew Bangham, Enrico Coen

Genetic Control of Organ Shape and Tissue Polarity

Amelia A. Green, J. Richard Kennaway, Andrew I. Hanna, J. Andrew Bangham, Enrico Coen

A Polarised Population of Dynamic Microtubules Mediates Homeostatic Length Control in Animal Cells

Remigio Picone, Xiaoyun Ren, Kenzo D. Ivanovitch, Jon D. W. Clarke, Rachel A. McKendry, Buzz Baum

Control of Directed Cell Migration In Vivo by Membrane-to-Cortex Attachment

Alba Diz-Muñoz, Michael Krieg, Martin Bergert, Itziar Ibarlucea-Benitez, Daniel J. Muller, Ewa Paluch, Carl-Philipp Heisenberg

WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal Bodies

Salah Mahmoudi, Sofia Henriksson, Irene Weibrecht, Stephen Smith, Ola Söderberg, Staffan Strömblad, Klas G. Wiman, Marianne Farnebo

Neighbourhood Continuity Is Not Required for Correct Testis Gene Expression in Drosophila

Lisa A. Meadows, Yuk Sang Chan, John Roote, Steven Russell

Phenotypic Consequences of Copy Number Variation: Insights from Smith-Magenis and Potocki-Lupski Syndrome Mouse Models

Guénola Ricard, Jessica Molina, Jacqueline Chrast, Wenli Gu, Nele Gheldof, Sylvain Pradervand, Frédéric Schütz, Juan I. Young, James R. Lupski, Alexandre Reymond, Katherina Walz

The DNA Methylome of Human Peripheral Blood Mononuclear Cells

Yingrui Li, Jingde Zhu, Geng Tian, Ning Li, Qibin Li, Mingzhi Ye, Hancheng Zheng, Jian Yu, Honglong Wu, Jihua Sun, Hongyu Zhang, Quan Chen, Ruibang Luo, Minfeng Chen, Yinghua He, Xin Jin, Qinghui Zhang, Chang Yu, Guangyu Zhou, Jinfeng Sun, Yebo Huang, Huisong Zheng, Hongzhi Cao, Xiaoyu Zhou, Shicheng Guo, Xueda Hu, Xin Li, Karsten Kristiansen, Lars Bolund, Jiujin Xu, Wen Wang, Huanming Yang, Jian Wang, Ruiqiang Li, Stephan Beck, Jun Wang, Xiuqing Zhang

The Honey Bee Epigenomes: Differential Methylation of Brain DNA in Queens and Workers

Frank Lyko, Sylvain Foret, Robert Kucharski, Stephan Wolf, Cassandra Falckenhayn, Ryszard Maleszka

Control of Transcription by Cell Size

Chia-Yung Wu, P. Alexander Rolfe, David K. Gifford, Gerald R. Fink

Regulation of Na+/K+ ATPase Transport Velocity by RNA Editing

Claudia Colina, Juan Pablo Palavicini, Deepa Srikumar, Miguel Holmgren, Joshua J. C. Rosenthal

The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation

Julien Moretti, Patricia Chastagner, Stefano Gastaldello, Sara F. Heuss, Annette M. Dirac, René Bernards, Maria G. Masucci, Alain Israël, Christel Brou

The Function and Three-Dimensional Structure of a Thromboxane A2/Cysteinyl Leukotriene-Binding Protein from the Saliva of a Mosquito Vector of the Malaria Parasite

Patricia H. Alvarenga, Ivo M. B. Francischetti, Eric Calvo, Anderson Sá-Nunes, José M. C. Ribeiro, John F. Andersen