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Table of Contents: August 2010

COVER

Genetic diversity in dog breeds.

Image Credit: Elaine Ostrander
Issue Image

The two dog breeds shown demonstrate the high level of diversity seen in dog breeds (see Boyko et al., e 1000451). The larger black dog is an Afghan hound, which is a classic sight hound. The smaller white dog is a Chihuahua mix and is among the smallest of the domestic dog breeds. In addition to body size, the dogs differ in fur length and texture, skull shape, and leg length.

Synopses

Essay

Book Review/Science in the Media

Primer

Mens Sana In Corpore Sano”: Exercise and Hypothalamic ER Stress

Pablo Blanco Martínez de Morentin, Miguel López

Community Page

Incorporating Genomics and Bioinformatics across the Life Sciences Curriculum

Jayna L. Ditty, Christopher A. Kvaal, Brad Goodner, Sharyn K. Freyermuth, Cheryl Bailey, Robert A. Britton, Stuart G. Gordon, Sabine Heinhorst, Kelynne Reed, Zhaohui Xu, Erin R. Sanders-Lorenz, Seth Axen, Edwin Kim, Mitrick Johns, Kathleen Scott, Cheryl A. Kerfeld

Research Articles

Aging in a Long-Lived Clonal Tree

Dilara Ally, Kermit Ritland, Sarah P. Otto

Precise Temperature Compensation of Phase in a Rhythmic Motor Pattern

Lamont S. Tang, Marie L. Goeritz, Jonathan S. Caplan, Adam L. Taylor, Mehmet Fisek, Eve Marder

Distinct Olfactory Signaling Mechanisms in the Malaria Vector Mosquito Anopheles gambiae

Chao Liu, R. Jason Pitts, Jonathan D. Bohbot, Patrick L. Jones, Guirong Wang, Laurence J. Zwiebel

IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition

Eduardo R. Ropelle, Marcelo B. Flores, Dennys E. Cintra, Guilherme Z. Rocha, José R. Pauli, Joseane Morari, Claudio T. de Souza, Juliana C. Moraes, Patrícia O. Prada, Dioze Guadagnini, Rodrigo M. Marin, Alexandre G. Oliveira, Taize M. Augusto, Hernandes F. Carvalho, Lício A. Velloso, Mario J. A. Saad, José B. C. Carvalheira

A Short Receptor Downregulates JAK/STAT Signalling to Control the Drosophila Cellular Immune Response

Rami Makki, Marie Meister, Delphine Pennetier, Jean-Michel Ubeda, Anne Braun, Virginie Daburon, Joanna Krzemień, Henri-Marc Bourbon, Rui Zhou, Alain Vincent, Michèle Crozatier

TRIM5 Suppresses Cross-Species Transmission of a Primate Immunodeficiency Virus and Selects for Emergence of Resistant Variants in the New Species

Andrea Kirmaier, Fan Wu, Ruchi M. Newman, Laura R. Hall, Jennifer S. Morgan, Shelby O'Connor, Preston A. Marx, Mareike Meythaler, Simoy Goldstein, Alicia Buckler-White, Amitinder Kaur, Vanessa M. Hirsch, Welkin E. Johnson

A Complete Developmental Sequence of a Drosophila Neuronal Lineage as Revealed by Twin-Spot MARCM

Hung-Hsiang Yu, Chih-Fei Kao, Yisheng He, Peng Ding, Jui-Chun Kao, Tzumin Lee

Foxp1 and Lhx1 Coordinate Motor Neuron Migration with Axon Trajectory Choice by Gating Reelin Signalling

Elena Palmesino, David L. Rousso, Tzu-Jen Kao, Avihu Klar, Ed Laufer, Osamu Uemura, Hitoshi Okamoto, Bennett G. Novitch, Artur Kania

Prox1 Is Required for Granule Cell Maturation and Intermediate Progenitor Maintenance During Brain Neurogenesis

Alfonso Lavado, Oleg V. Lagutin, Lionel M. L. Chow, Suzanne J. Baker, Guillermo Oliver

The Somatic Reproductive Tissues of C. elegans Promote Longevity through Steroid Hormone Signaling

Tracy M. Yamawaki, Jennifer R. Berman, Monika Suchanek-Kavipurapu, Mark McCormick, Marta Maria Gaglia, Seung-Jae Lee, Cynthia Kenyon

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

Della C. David, Noah Ollikainen, Jonathan C. Trinidad, Michael P. Cary, Alma L. Burlingame, Cynthia Kenyon

A Simple Genetic Architecture Underlies Morphological Variation in Dogs

Adam R. Boyko, Pascale Quignon, Lin Li, Jeffrey J. Schoenebeck, Jeremiah D. Degenhardt, Kirk E. Lohmueller, Keyan Zhao, Abra Brisbin, Heidi G. Parker, Bridgett M. vonHoldt, Michele Cargill, Adam Auton, Andy Reynolds, Abdel G. Elkahloun, Marta Castelhano, Dana S. Mosher, Nathan B. Sutter, Gary S. Johnson, John Novembre, Melissa J. Hubisz, Adam Siepel, Robert K. Wayne, Carlos D. Bustamante, Elaine A. Ostrander

Quantitative Analysis of the Drosophila Segmentation Regulatory Network Using Pattern Generating Potentials

Majid Kazemian, Charles Blatti, Adam Richards, Michael McCutchan, Noriko Wakabayashi-Ito, Ann S. Hammonds, Susan E. Celniker, Sudhir Kumar, Scot A. Wolfe, Michael H. Brodsky, Saurabh Sinha

MLL2 Is Required in Oocytes for Bulk Histone 3 Lysine 4 Trimethylation and Transcriptional Silencing

Claudia V. Andreu-Vieyra, Ruihong Chen, Julio E. Agno, Stefan Glaser, Konstantinos Anastassiadis, A. Francis Stewart, Martin M. Matzuk

Tyrosine-Phosphorylated Caveolin-1 Blocks Bacterial Uptake by Inducing Vav2-RhoA-Mediated Cytoskeletal Rearrangements

Jan Peter Boettcher, Marieluise Kirchner, Yuri Churin, Alexis Kaushansky, Malvika Pompaiah, Hans Thorn, Volker Brinkmann, Gavin MacBeath, Thomas F. Meyer

A New Type of Proton Coordination in an F1Fo-ATP Synthase Rotor Ring

Laura Preiss, Özkan Yildiz, David B. Hicks, Terry A. Krulwich, Thomas Meier