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Table of Contents: March 2010

COVER

Beware of crossing axons.

Image Credit: Adrien Braure, modified by Alain Chédotal
Issue Image

During development, growing axons frequently cross the midline of the body to connect the two sides of the nervous system. This process requires the Robo3 receptor, which is mutated in people suffering a rare congenital disorder. Conditional elimination of Robo3 from selected subsets of neurons in the mouse provides a model of this congenital strabismus and sheds light on the need for correct axon guidance in the development of specific behaviors (see Renier et al., e1000325).

Synopses

A Fatal Switch for Corals?

Elizabeth Whiteman

Essay

Canine Morphology: Hunting for Genes and Tracking Mutations

Abigail L. Shearin, Elaine A. Ostrander

Perspective

Indigenous Lands, Protected Areas, and Slowing Climate Change

Taylor H. Ricketts, Britaldo Soares-Filho, Gustavo A. B. da Fonseca, Daniel Nepstad, Alexander Pfaff, Annie Petsonk, Anthony Anderson, Doug Boucher, Andrea Cattaneo, Marc Conte, Ken Creighton, Lawrence Linden, Claudio Maretti, Paulo Moutinho, Roger Ullman, Ray Victurine

Book Review/Science in the Media

Fire in the Quill

Armin Schneider

Primers

Centromeres Convert but Don't Cross

Paul B. Talbert, Steven Henikoff

Research Articles

Predation upon Hatchling Dinosaurs by a New Snake from the Late Cretaceous of India

Jeffrey A. Wilson, Dhananjay M. Mohabey, Shanan E. Peters, Jason J. Head

How Microbial Community Composition Regulates Coral Disease Development

Justin Mao-Jones, Kim B. Ritchie, Laura E. Jones, Stephen P. Ellner

Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

Emily S. Sena, H. Bart van der Worp, Philip M. W. Bath, David W. Howells, Malcolm R. Macleod

Enhanced Memory for Scenes Presented at Behaviorally Relevant Points in Time

Jeffrey Y. Lin, Amanda D. Pype, Scott O. Murray, Geoffrey M. Boynton

Irradiation Selects for p53-Deficient Hematopoietic Progenitors

Andriy Marusyk, Christopher C. Porter, Vadym Zaberezhnyy, James DeGregori

Genetic Dissection of the Function of Hindbrain Axonal Commissures

Nicolas Renier, Martijn Schonewille, Fabrice Giraudet, Aleksandra Badura, Marc Tessier-Lavigne, Paul Avan, Chris I. De Zeeuw, Alain Chédotal

Widespread Gene Conversion in Centromere Cores

Jinghua Shi, Sarah E. Wolf, John M. Burke, Gernot G. Presting, Jeffrey Ross-Ibarra, R. Kelly Dawe

Binding Site Turnover Produces Pervasive Quantitative Changes in Transcription Factor Binding between Closely Related Drosophila Species

Robert K. Bradley, Xiao-Yong Li, Cole Trapnell, Stuart Davidson, Lior Pachter, Hou Cheng Chu, Leath A. Tonkin, Mark D. Biggin, Michael B. Eisen

Need-Based Up-Regulation of Protein Levels in Response to Deletion of Their Duplicate Genes

Alexander DeLuna, Michael Springer, Marc W. Kirschner, Roy Kishony

Evolutionary Tinkering with Conserved Components of a Transcriptional Regulatory Network

Hugo Lavoie, Hervé Hogues, Jaideep Mallick, Adnane Sellam, André Nantel, Malcolm Whiteway

Spatial Epigenetic Control of Mono- and Bistable Gene Expression

János Z. Kelemen, Prasuna Ratna, Simone Scherrer, Attila Becskei

Sequestration of the Aβ Peptide Prevents Toxicity and Promotes Degradation In Vivo

Leila M. Luheshi, Wolfgang Hoyer, Teresa Pereira de Barros, Iris van Dijk Härd, Ann-Christin Brorsson, Bertil Macao, Cecilia Persson, Damian C. Crowther, David A. Lomas, Stefan Ståhl, Christopher M. Dobson, Torleif Härd

Fumarase: A Mitochondrial Metabolic Enzyme and a Cytosolic/Nuclear Component of the DNA Damage Response

Ohad Yogev, Orli Yogev, Esti Singer, Eitan Shaulian, Michal Goldberg, Thomas D. Fox, Ophry Pines

Discovery of Unique Lanthionine Synthetases Reveals New Mechanistic and Evolutionary Insights

Yuki Goto, Bo Li, Jan Claesen, Yanxiang Shi, Mervyn J. Bibb, Wilfred A. van der Donk