Table of Contents: November 2006


Arthritic limbs from mice with autoimmune disease.

Image Credit: Nevil Singh
Issue Image

A dynamic tuning process restricts the responsiveness of autoreactive T cells, but its relative inefficiency in abrogating effector functionality results in arthritis and autoantibody production (bottom panels). Singh et al. examine the separable contributions of intrinsic and extrinsic regulatory processes to the control of peripheral autoimmunity.



Bushes in the Tree of Life

Antonis Rokas, Sean B Carroll

Community Page

BioGeomancer: Automated Georeferencing to Map the World's Biodiversity Data

Robert P Guralnick, John Wieczorek, Reed Beaman, Robert J Hijmans , the BioGeomancer Working Group

Research Articles

Two-Step Recruitment of RNA-Directed DNA Methylation to Tandem Repeats

Simon W.-L Chan, Xiaoyu Zhang, Yana V Bernatavichute, Steven E Jacobsen

Target DNA Structure Plays a Critical Role in RAG Transposition

Jennifer E Posey, Malgorzata J Pytlos, Richard R Sinden, David B Roth

A Role for PCNA Ubiquitination in Immunoglobulin Hypermutation

Hiroshi Arakawa, George-Lucian Moldovan, Huseyin Saribasak, Nesibe Nur Saribasak, Stefan Jentsch, Jean-Marie Buerstedde

Human Immunodeficiency Virus Impairs Reverse Cholesterol Transport from Macrophages

Zahedi Mujawar, Honor Rose, Matthew P Morrow, Tatiana Pushkarsky, Larisa Dubrovsky, Nigora Mukhamedova, Ying Fu, Anthony Dart, Jan M Orenstein, Yuri V Bobryshev, Michael Bukrinsky, Dmitri Sviridov

Assembly Factor Omp85 Recognizes Its Outer Membrane Protein Substrates by a Species-Specific C-Terminal Motif

Viviane Robert, Elena B Volokhina, Freya Senf, Martine P Bos, Patrick Van Gelder, Jan Tommassen

The Liganding of Glycolipid Transfer Protein Is Controlled by Glycolipid Acyl Structure

Lucy Malinina, Margarita L Malakhova, Alex T Kanack, Min Lu, Ruben Abagyan, Rhoderick E Brown, Dinshaw J Patel

Ammonium Toxicity and Potassium Limitation in Yeast

David C Hess, Wenyun Lu, Joshua D Rabinowitz, David Botstein

Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins

D. Thomas Rutkowski, Stacey M Arnold, Corey N Miller, Jun Wu, Jack Li, Kathryn M Gunnison, Kazutoshi Mori, Amir A. Sadighi Akha, David Raden, Randal J Kaufman

Ablation of PGC-1β Results in Defective Mitochondrial Activity, Thermogenesis, Hepatic Function, and Cardiac Performance

Christopher J Lelliott, Gema Medina-Gomez, Natasa Petrovic, Adrienn Kis, Helena M Feldmann, Mikael Bjursell, Nadeene Parker, Keira Curtis, Mark Campbell, Ping Hu, Dongfang Zhang, Sheldon E Litwin, Vlad G Zaha, Kimberly T Fountain, Sihem Boudina, Mercedes Jimenez-Linan, Margaret Blount, Miguel Lopez, Aline Meirhaeghe, Mohammad Bohlooly-Y, Leonard Storlien, Maria Strömstedt, Michael Snaith, Matej Orešič, E. Dale Abel, Barbara Cannon, Antonio Vidal-Puig

Plasticity of Astrocytic Coverage and Glutamate Transporter Expression in Adult Mouse Cortex

Christel Genoud, Charles Quairiaux, Pascal Steiner, Harald Hirling, Egbert Welker, Graham W Knott

Rapid Redistribution of Synaptic PSD-95 in the Neocortex In Vivo

Noah W Gray, Robby M Weimer, Ingrid Bureau, Karel Svoboda

A Signaling Network for Patterning of Neuronal Connectivity in the Drosophila Brain

Mohammed Srahna, Maarten Leyssen, Ching Man Choi, Lee G Fradkin, Jasprina N Noordermeer, Bassem A Hassan

Intracellular Demography and the Dynamics of Salmonella enterica Infections

Sam P Brown, Stephen J Cornell, Mark Sheppard, Andrew J Grant, Duncan J Maskell, Bryan T Grenfell, Pietro Mastroeni

Phenotypic Plasticity Opposes Species Invasions by Altering Fitness Surface

Scott D Peacor, Stefano Allesina, Rick L Riolo, Mercedes Pascual

The Marine Viromes of Four Oceanic Regions

Florent E Angly, Ben Felts, Mya Breitbart, Peter Salamon, Robert A Edwards, Craig Carlson, Amy M Chan, Matthew Haynes, Scott Kelley, Hong Liu, Joseph M Mahaffy, Jennifer E Mueller, Jim Nulton, Robert Olson, Rachel Parsons, Steve Rayhawk, Curtis A Suttle, Forest Rohwer

Seed Dispersal and Spatial Pattern in Tropical Trees

Tristram G Seidler, Joshua B Plotkin

Conservation Planning for Ecosystem Services

Kai M. A Chan, M. Rebecca Shaw, David R Cameron, Emma C Underwood, Gretchen C Daily


Correction: Preserving Genome Integrity: The DdrA Protein of Deinococcus radiodurans R1

Dennis R Harris, Masashi Tanaka, Sergei V Saveliev, Edmond Jolivet, Ashlee M Earl, Michael M Cox, John R Battista