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Research Article

Reduced Juvenile Long-Term Depression in Tuberous Sclerosis Complex Is Mitigated in Adults by Compensatory Recruitment of mGluR5 and Erk Signaling

  • Wyatt B. Potter,

    Affiliations: Department of Neuroscience, Medical Science Center, University of Wisconsin–Madison, Madison, Wisconsin, United States of America, Neuroscience Training Program, University of Wisconsin–Madison, Madison, Wisconsin, United States of America

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  • Trina Basu,

    Affiliations: Department of Neuroscience, Medical Science Center, University of Wisconsin–Madison, Madison, Wisconsin, United States of America, Neuroscience Training Program, University of Wisconsin–Madison, Madison, Wisconsin, United States of America

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  • Kenneth J. O'Riordan,

    Affiliation: Department of Neurology, William S. Middleton Memorial VA Hospital and University of Wisconsin–Madison, Madison, Wisconsin, United States of America

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  • Allison Kirchner,

    Affiliation: Department of Neuroscience, Medical Science Center, University of Wisconsin–Madison, Madison, Wisconsin, United States of America

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  • Paul Rutecki,

    Affiliation: Department of Neurology, William S. Middleton Memorial VA Hospital and University of Wisconsin–Madison, Madison, Wisconsin, United States of America

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  • Corinna Burger,

    Affiliation: Department of Neurology, William S. Middleton Memorial VA Hospital and University of Wisconsin–Madison, Madison, Wisconsin, United States of America

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  • Avtar Roopra mail

    asroopra@wisc.edu

    Affiliation: Department of Neuroscience, Medical Science Center, University of Wisconsin–Madison, Madison, Wisconsin, United States of America

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  • Published: August 13, 2013
  • DOI: 10.1371/journal.pbio.1001627

About the Authors

Wyatt B. Potter, Trina Basu, Allison Kirchner, Avtar Roopra
Department of Neuroscience, Medical Science Center, University of Wisconsin–Madison, Madison, Wisconsin, United States of America
Wyatt B. Potter, Trina Basu
Neuroscience Training Program, University of Wisconsin–Madison, Madison, Wisconsin, United States of America
Kenneth J. O'Riordan, Paul Rutecki, Corinna Burger
Department of Neurology, William S. Middleton Memorial VA Hospital and University of Wisconsin–Madison, Madison, Wisconsin, United States of America

Corresponding Author

Email: asroopra@wisc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: WBP CB PR AR. Performed the experiments: WBP KJO AK TB. Analyzed the data: WBP KJO AK TB CB AR. Contributed reagents/materials/analysis tools: AR. Wrote the paper: WBP AR.