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Research Article

Par-1 Regulates Tissue Growth by Influencing Hippo Phosphorylation Status and Hippo-Salvador Association

  • Hong-Ling Huang equal contributor,

    equal contributor Contributed equally to this work with: Hong-Ling Huang, Shimin Wang

    Affiliation: State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China

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  • Shimin Wang equal contributor,

    equal contributor Contributed equally to this work with: Hong-Ling Huang, Shimin Wang

    Affiliation: State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China

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  • Meng-Xin Yin,

    Affiliation: State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China

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  • Liang Dong,

    Affiliation: State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China

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  • Chao Wang,

    Affiliation: State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China

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  • Wei Wu,

    Affiliation: State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China

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  • Yi Lu,

    Affiliation: State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China

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  • Miao Feng,

    Affiliation: State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China

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  • Chuanyang Dai,

    Affiliation: Shanghai Ocean University, Shanghai, P.R. China

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  • Xiaocan Guo,

    Affiliation: Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, P.R. China

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  • Li Li,

    Affiliation: Institute of Ageing Research, Hangzhou Normal University, Hangzhou, Zhejiang, P.R. China

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  • Bin Zhao,

    Affiliation: Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, P.R. China

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  • Zhaocai Zhou,

    Affiliation: State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China

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  • Hongbin Ji,

    Affiliation: State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China

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  • Jin Jiang,

    Affiliation: Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Yun Zhao mail,

    yunzhao@sibcb.ac.cn (YZ); xyliu@sibcb.ac.cn (XYL); rayzhang@sibcb.ac.cn (LZ)

    Affiliation: State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China

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  • Xin-Yuan Liu mail,

    yunzhao@sibcb.ac.cn (YZ); xyliu@sibcb.ac.cn (XYL); rayzhang@sibcb.ac.cn (LZ)

    Affiliation: State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China

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  • Lei Zhang mail

    yunzhao@sibcb.ac.cn (YZ); xyliu@sibcb.ac.cn (XYL); rayzhang@sibcb.ac.cn (LZ)

    Affiliation: State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China

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  • Published: August 06, 2013
  • DOI: 10.1371/journal.pbio.1001620

About the Authors

Hong-Ling Huang, Shimin Wang, Meng-Xin Yin, Liang Dong, Chao Wang, Wei Wu, Yi Lu, Miao Feng, Zhaocai Zhou, Hongbin Ji, Yun Zhao, Xin-Yuan Liu, Lei Zhang
State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China
Chuanyang Dai
Shanghai Ocean University, Shanghai, P.R. China
Jin Jiang
Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Xiaocan Guo, Bin Zhao
Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, P.R. China
Li Li
Institute of Ageing Research, Hangzhou Normal University, Hangzhou, Zhejiang, P.R. China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: HLH SW XYL LZ. Performed the experiments: HLH SW LD XG. Analyzed the data: HLH SW MXY BZ ZZ HJ JJ YZ XYL LZ. Contributed reagents/materials/analysis tools: CW WW YL MF CD LL BZ ZZ HJ JJ YZ. Wrote the paper: HLH SW MXY LZ.