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Research Article

Genome-Wide RNA Polymerase II Profiles and RNA Accumulation Reveal Kinetics of Transcription and Associated Epigenetic Changes During Diurnal Cycles

  • Gwendal Le Martelot equal contributor,

    equal contributor Contributed equally to this work with: Gwendal Le Martelot, Donatella Canella, Laura Symul, Eugenia Migliavacca

    Affiliation: Department of Molecular Biology, University of Geneva, Geneva, Switzerland

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  • Donatella Canella equal contributor,

    equal contributor Contributed equally to this work with: Gwendal Le Martelot, Donatella Canella, Laura Symul, Eugenia Migliavacca

    Affiliation: Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland

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  • Laura Symul equal contributor,

    equal contributor Contributed equally to this work with: Gwendal Le Martelot, Donatella Canella, Laura Symul, Eugenia Migliavacca

    Affiliation: The Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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  • Eugenia Migliavacca equal contributor,

    equal contributor Contributed equally to this work with: Gwendal Le Martelot, Donatella Canella, Laura Symul, Eugenia Migliavacca

    Affiliation: Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland

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  • Federica Gilardi,

    Affiliation: Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland

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  • Robin Liechti,

    Affiliation: Vital IT, Swiss Institute of Bioinformatics, Lausanne, Switzerland

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  • Olivier Martin,

    Affiliation: Vital IT, Swiss Institute of Bioinformatics, Lausanne, Switzerland

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  • Keith Harshman,

    Affiliation: Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland

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  • Mauro Delorenzi,

    Affiliation: Département de Formation et de Recherche, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland

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  • Béatrice Desvergne,

    Affiliation: Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland

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  • Winship Herr,

    Affiliation: Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland

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  • Bart Deplancke,

    Affiliation: The Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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  • Ueli Schibler,

    Affiliation: Department of Molecular Biology, University of Geneva, Geneva, Switzerland

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  • Jacques Rougemont,

    Affiliation: Bioinformatics and Biostatistics Core Facility, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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  • Nicolas Guex,

    Affiliation: Vital IT, Swiss Institute of Bioinformatics, Lausanne, Switzerland

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  • Nouria Hernandez mail,

    nouria.hernandez@unil.ch (NH); felix.naef@epfl.ch (FN)

    Affiliation: Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland

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  • Felix Naef mail,

    nouria.hernandez@unil.ch (NH); felix.naef@epfl.ch (FN)

    Affiliation: The Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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  • the CycliX consortium

    A complete list of consortium authors appears in the Acknowledgments section.

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  • Published: November 27, 2012
  • DOI: 10.1371/journal.pbio.1001442

About the Authors

Gwendal Le Martelot, Ueli Schibler
Department of Molecular Biology, University of Geneva, Geneva, Switzerland
Donatella Canella, Eugenia Migliavacca, Federica Gilardi, Keith Harshman, Béatrice Desvergne, Winship Herr, Nouria Hernandez
Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
Laura Symul, Bart Deplancke, Felix Naef
The Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
Robin Liechti, Olivier Martin, Nicolas Guex
Vital IT, Swiss Institute of Bioinformatics, Lausanne, Switzerland
Mauro Delorenzi
Département de Formation et de Recherche, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
Jacques Rougemont
Bioinformatics and Biostatistics Core Facility, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: M Delorenzi, B Desvergne, W Herr, B Deplancke, U Schibler, J Rougemont, N Guex, N Hernandez, F Naef. Performed the experiments: G Le Martelot, D Canella, F Gilardi. Analyzed the data: G Le Martelot, L Symul, E Migliavacca, R Liechti, O Martin. Contributed reagents/materials/analysis tools: K Harshman. Wrote the paper: G Le Martelot, L Symul, U Schibler, N Hernandez, F Naef. The consortium provided the logistics and infrastructure required to perform this study. The contributions of individual members are specified by the headings under which their names are listed.