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Research Article

The Nuclear Effector of Wnt-Signaling, Tcf1, Functions as a T-Cell–Specific Tumor Suppressor for Development of Lymphomas

  • Machteld M. Tiemessen,

    Affiliations: Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands, Department Immunology, ErasmusMC, Rotterdam, The Netherlands

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  • Miranda R. M. Baert,

    Affiliations: Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands, Department Immunology, ErasmusMC, Rotterdam, The Netherlands

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  • Tom Schonewille,

    Affiliation: Department Immunology, ErasmusMC, Rotterdam, The Netherlands

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  • Martijn H. Brugman,

    Affiliation: Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands

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  • Farbod Famili,

    Affiliation: Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands

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  • Daniela C. F. Salvatori,

    Affiliation: Central Laboratory Animal Facility, Leiden University Medical Center, Leiden, The Netherlands

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  • Jules P. P. Meijerink,

    Affiliation: Department of Pediatric Oncology/Hematology, Erasmus MC/Sophia's Children's Hospital, Rotterdam, The Netherlands

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  • Ugur Ozbek,

    Affiliation: Department of Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey

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  • Hans Clevers,

    Affiliation: Hubrecht Laboratory, Utrecht, The Netherlands

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  • Jacques J. M. van Dongen,

    Affiliation: Department Immunology, ErasmusMC, Rotterdam, The Netherlands

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  • Frank J. T. Staal mail

    f.j.t.staal@lumc.nl

    Affiliations: Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands, Department Immunology, ErasmusMC, Rotterdam, The Netherlands

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  • Published: November 20, 2012
  • DOI: 10.1371/journal.pbio.1001430

About the Authors

Machteld M. Tiemessen, Miranda R. M. Baert, Martijn H. Brugman, Farbod Famili, Frank J. T. Staal
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
Machteld M. Tiemessen, Miranda R. M. Baert, Tom Schonewille, Jacques J. M. van Dongen, Frank J. T. Staal
Department Immunology, ErasmusMC, Rotterdam, The Netherlands
Daniela C. F. Salvatori
Central Laboratory Animal Facility, Leiden University Medical Center, Leiden, The Netherlands
Jules P. P. Meijerink
Department of Pediatric Oncology/Hematology, Erasmus MC/Sophia's Children's Hospital, Rotterdam, The Netherlands
Ugur Ozbek
Department of Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey
Hans Clevers
Hubrecht Laboratory, Utrecht, The Netherlands

Corresponding Author

Email: f.j.t.staal@lumc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: MMT FJTS JJMvD. Performed the experiments: MMT MRMB TS FF DS. Analyzed the data: MHB FJTS MMT. Contributed reagents/materials/analysis tools: HC JPPM. Wrote the paper: MMT FJTS. Discussions related to leukemia development: UO.