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Research Article

An Autism-Associated Variant of Epac2 Reveals a Role for Ras/Epac2 Signaling in Controlling Basal Dendrite Maintenance in Mice

  • Deepak P. Srivastava equal contributor,

    equal contributor Contributed equally to this work with: Deepak P. Srivastava, Kevin M. Woolfrey

    Affiliations: Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America, Department of Neuroscience & Centre for the Cellular Basis of Behaviour, The James Black Centre, King's College London, Institute of Psychiatry, London, United Kingdom

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  • Kevin M. Woolfrey equal contributor,

    equal contributor Contributed equally to this work with: Deepak P. Srivastava, Kevin M. Woolfrey

    Affiliation: Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

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  • Kelly A. Jones,

    Affiliation: Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

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  • Charles T. Anderson,

    Affiliation: Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

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  • Katharine R. Smith,

    Affiliation: Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

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  • Theron A. Russell,

    Affiliation: Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

    X
  • Hyerin Lee,

    Affiliation: Weinberg College of Arts and Sciences, Northwestern University, Evanston, Illinois, United States of America

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  • Marina V. Yasvoina,

    Affiliation: Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

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  • David L. Wokosin,

    Affiliation: Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

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  • P. Hande Ozdinler,

    Affiliations: Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America, Cognitive Neurology and Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America, Lurie Cancer Research Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

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  • Gordon M. G. Shepherd,

    Affiliation: Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

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  • Peter Penzes mail

    p-penzes@northwestern.edu

    Affiliations: Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America, Lurie Cancer Research Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America, Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

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  • Published: June 26, 2012
  • DOI: 10.1371/journal.pbio.1001350

About the Authors

Deepak P. Srivastava, Kevin M. Woolfrey, Kelly A. Jones, Charles T. Anderson, Katharine R. Smith, Theron A. Russell, David L. Wokosin, Gordon M. G. Shepherd, Peter Penzes
Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
Deepak P. Srivastava
Department of Neuroscience & Centre for the Cellular Basis of Behaviour, The James Black Centre, King's College London, Institute of Psychiatry, London, United Kingdom
Hyerin Lee
Weinberg College of Arts and Sciences, Northwestern University, Evanston, Illinois, United States of America
Marina V. Yasvoina, P. Hande Ozdinler
Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
P. Hande Ozdinler
Cognitive Neurology and Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
P. Hande Ozdinler, Peter Penzes
Lurie Cancer Research Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
Peter Penzes
Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

Corresponding Author

Email: p-penzes@northwestern.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: DPS KMW PHO GMGS PP. Performed the experiments: DPS KMW KAJ CTA TAR HL MVY KRS. Analyzed the data: DPS KMW CTA KRS DLW PHO GMGS PP. Contributed reagents/materials/analysis tools: DLW PHO GMGS. Wrote the paper: DPS KMW KAJ PP.