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Research Article

Regulation of Brain Tumor Dispersal by NKCC1 Through a Novel Role in Focal Adhesion Regulation

  • Tomas Garzon-Muvdi,

    Affiliation: Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Paula Schiapparelli,

    Affiliation: Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Colette ap Rhys,

    Affiliation: Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Hugo Guerrero-Cazares,

    Affiliation: Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Christopher Smith,

    Affiliation: Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Deok-Ho Kim,

    Affiliations: Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Bioengineering, University of Washington, Seattle, Washington, United States of America

    X
  • Lyonell Kone,

    Affiliation: Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Harrison Farber,

    Affiliation: Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Danielle Y. Lee,

    Affiliation: Department of Environmental Health Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Steven S. An,

    Affiliations: Department of Environmental Health Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Physical Sciences in Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Andre Levchenko mail,

    aquinon2@jhmi.edu (AQH); alev@jhu.edu (AL)

    Affiliation: Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Alfredo Quiñones-Hinojosa mail

    aquinon2@jhmi.edu (AQH); alev@jhu.edu (AL)

    Affiliations: Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Published: May 01, 2012
  • DOI: 10.1371/journal.pbio.1001320

About the Authors

Tomas Garzon-Muvdi, Paula Schiapparelli, Colette ap Rhys, Hugo Guerrero-Cazares, Deok-Ho Kim, Lyonell Kone, Harrison Farber, Alfredo Quiñones-Hinojosa
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Christopher Smith, Deok-Ho Kim, Andre Levchenko
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Deok-Ho Kim
Department of Bioengineering, University of Washington, Seattle, Washington, United States of America
Danielle Y. Lee, Steven S. An
Department of Environmental Health Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Steven S. An
Department of Physical Sciences in Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Alfredo Quiñones-Hinojosa
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: TGM PS AQH AL DHK DYL SA. Performed the experiments: TGM PS HGC CaP LK HF AQH AL DHK DYL SA. Analyzed the data: TGM PS CaP HGC SA DHK AQH. Contributed reagents/materials/analysis tools: TGM CaP HGC DHK. Wrote the paper: TGM PS CaP HGC AQH AL DHK DYL SA.