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Research Article

Hormonal Signal Amplification Mediates Environmental Conditions during Development and Controls an Irreversible Commitment to Adulthood

  • Oren N. Schaedel,

    Affiliation: Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena, California, United States of America

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  • Birgit Gerisch,

    Affiliation: Max-Planck-Institute for Biology of Ageing, Koeln, Germany

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  • Adam Antebi mail,

    pws@caltech.edu (PWS); Antebi@age.mpg.de (AA)

    Affiliations: Max-Planck-Institute for Biology of Ageing, Koeln, Germany, Baylor College of Medicine, Huffington Center on Aging, Houston, Texas, United States of America

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  • Paul W. Sternberg mail

    pws@caltech.edu (PWS); Antebi@age.mpg.de (AA)

    Affiliation: Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena, California, United States of America

    X
  • Published: April 10, 2012
  • DOI: 10.1371/journal.pbio.1001306

About the Authors

Oren N. Schaedel, Paul W. Sternberg
Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena, California, United States of America
Birgit Gerisch, Adam Antebi
Max-Planck-Institute for Biology of Ageing, Koeln, Germany
Adam Antebi
Baylor College of Medicine, Huffington Center on Aging, Houston, Texas, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: OS BG AA. Performed the experiments: OS BG. Analyzed the data: OS BG AA PWS. Contributed reagents/materials/analysis tools: OS BG. Wrote the paper: OS BG AA PWS.