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Research Article

NUP-1 Is a Large Coiled-Coil Nucleoskeletal Protein in Trypanosomes with Lamin-Like Functions

  • Kelly N. DuBois,

    Affiliation: Department of Pathology, University of Cambridge, Cambridge, United Kingdom

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  • Sam Alsford,

    Affiliation: London School of Hygiene & Tropical Medicine, London, United Kingdom

    X
  • Jennifer M. Holden,

    Affiliation: Department of Pathology, University of Cambridge, Cambridge, United Kingdom

    X
  • Johanna Buisson,

    Affiliation: Trypanosome Cell Biology Unit, Pasteur Institute and Centre National de la Recherche Scientifique, Paris, France

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  • Michal Swiderski,

    Affiliation: Wellcome Trust Center for Molecular Parasitology, University of Glasgow, Glasgow, United Kingdom

    X
  • Jean-Mathieu Bart,

    Affiliation: Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Cientificas, Granada, Spain

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  • Alexander V. Ratushny,

    Affiliations: The Institute for Systems Biology, Seattle, Washington, United States of America, Seattle Biomedical Research Institute, Seattle, Washington, United States of America

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  • Yakun Wan,

    Affiliation: The Institute for Systems Biology, Seattle, Washington, United States of America

    Current address: The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Science, Southeast University, Nanjing, China

    X
  • Philippe Bastin,

    Affiliation: Trypanosome Cell Biology Unit, Pasteur Institute and Centre National de la Recherche Scientifique, Paris, France

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  • J. David Barry,

    Affiliation: Wellcome Trust Center for Molecular Parasitology, University of Glasgow, Glasgow, United Kingdom

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  • Miguel Navarro,

    Affiliation: Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Cientificas, Granada, Spain

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  • David Horn,

    Affiliation: London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • John D. Aitchison,

    Affiliations: The Institute for Systems Biology, Seattle, Washington, United States of America, Seattle Biomedical Research Institute, Seattle, Washington, United States of America

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  • Michael P. Rout,

    Affiliation: The Rockefeller University, New York, New York, United States of America

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  • Mark C. Field mail

    mcf34@cam.ac.uk

    Affiliation: Department of Pathology, University of Cambridge, Cambridge, United Kingdom

    X
  • Published: March 27, 2012
  • DOI: 10.1371/journal.pbio.1001287

About the Authors

Kelly N. DuBois, Jennifer M. Holden, Mark C. Field
Department of Pathology, University of Cambridge, Cambridge, United Kingdom
Sam Alsford, David Horn
London School of Hygiene & Tropical Medicine, London, United Kingdom
Johanna Buisson, Philippe Bastin
Trypanosome Cell Biology Unit, Pasteur Institute and Centre National de la Recherche Scientifique, Paris, France
Michal Swiderski, J. David Barry
Wellcome Trust Center for Molecular Parasitology, University of Glasgow, Glasgow, United Kingdom
Jean-Mathieu Bart, Miguel Navarro
Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Cientificas, Granada, Spain
Alexander V. Ratushny, Yakun Wan, John D. Aitchison
The Institute for Systems Biology, Seattle, Washington, United States of America
Alexander V. Ratushny, John D. Aitchison
Seattle Biomedical Research Institute, Seattle, Washington, United States of America
Michael P. Rout
The Rockefeller University, New York, New York, United States of America

Corresponding Author

Email: mcf34@cam.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: KND SA PB JDB MN DH JDA MPR MCF. Performed the experiments: KND SA JMH JB MS JB AVR YW. Analyzed the data: KND SA JMH JB MS JB AVR YW PB JDB MN DH JDA MPR MCF. Wrote the paper: KND SA PB JDB MN DH JDA MPR MCF.