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Research Article

Facilitation of AMPA Receptor Synaptic Delivery as a Molecular Mechanism for Cognitive Enhancement

  • Shira Knafo equal contributor mail,

    equal contributor Contributed equally to this work with: Shira Knafo, César Venero

    jaesteban@cbm.uam.es (JAE), sknafo@cbm.uam.es (SK); cvenero@psi.uned.es (CV)

    Affiliations: Centro de Biología Molecular “Severo Ochoa,” Consejo Superior de Investigaciones Científicas (CSIC)/Universidad Autónoma de Madrid, Madrid, Spain, Instituto Cajal (CSIC), Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain

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  • César Venero equal contributor mail,

    equal contributor Contributed equally to this work with: Shira Knafo, César Venero

    jaesteban@cbm.uam.es (JAE), sknafo@cbm.uam.es (SK); cvenero@psi.uned.es (CV)

    Affiliation: Department of Psychobiology, Universidad Nacional de Educación a Distancia, Madrid, Spain

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  • Cristina Sánchez-Puelles,

    Affiliation: Centro de Biología Molecular “Severo Ochoa,” Consejo Superior de Investigaciones Científicas (CSIC)/Universidad Autónoma de Madrid, Madrid, Spain

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  • Inmaculada Pereda-Peréz,

    Affiliation: Department of Psychobiology, Universidad Nacional de Educación a Distancia, Madrid, Spain

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  • Ana Franco,

    Affiliation: Centro Nacional Biotecnología (CSIC), Universidad Autónoma de Madrid, Madrid, Spain

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  • Carmen Sandi,

    Affiliation: Brain Mind Institute, Ecole Polytechnique Federale de Lausanne (EPFL), Switzerland

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  • Luz M. Suárez,

    Affiliations: Instituto Cajal (CSIC), Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain, Servicio de Neurobiología-Investigación, Hospital Ramón y Cajal, IRYCIS, Madrid, Spain

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  • José M. Solís,

    Affiliation: Servicio de Neurobiología-Investigación, Hospital Ramón y Cajal, IRYCIS, Madrid, Spain

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  • Lidia Alonso-Nanclares,

    Affiliation: Instituto Cajal (CSIC), Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain

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  • Eduardo D. Martín,

    Affiliation: Departamento de Ciencias Médicas, Universidad de Castilla-la Mancha, Albacete, Spain

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  • Paula Merino-Serrais,

    Affiliation: Instituto Cajal (CSIC), Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain

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  • Erika Borcel,

    Affiliation: Department of Psychobiology, Universidad Nacional de Educación a Distancia, Madrid, Spain

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  • Shizhong Li,

    Affiliation: Protein Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Yongshuo Chen,

    Affiliation: Protein Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Juncal Gonzalez-Soriano,

    Affiliation: Department of Anatomy, Faculty of Veterinary Medicine, Complutense University, Madrid, Spain

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  • Vladimir Berezin,

    Affiliation: Protein Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Elisabeth Bock,

    Affiliation: Protein Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Javier DeFelipe,

    Affiliation: Instituto Cajal (CSIC), Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain

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  • José A. Esteban mail

    jaesteban@cbm.uam.es (JAE), sknafo@cbm.uam.es (SK); cvenero@psi.uned.es (CV)

    Affiliation: Centro de Biología Molecular “Severo Ochoa,” Consejo Superior de Investigaciones Científicas (CSIC)/Universidad Autónoma de Madrid, Madrid, Spain

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  • Published: February 21, 2012
  • DOI: 10.1371/journal.pbio.1001262

About the Authors

Shira Knafo, Cristina Sánchez-Puelles, José A. Esteban
Centro de Biología Molecular “Severo Ochoa,” Consejo Superior de Investigaciones Científicas (CSIC)/Universidad Autónoma de Madrid, Madrid, Spain
Shira Knafo, Luz M. Suárez, Lidia Alonso-Nanclares, Paula Merino-Serrais, Javier DeFelipe
Instituto Cajal (CSIC), Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
César Venero, Inmaculada Pereda-Peréz, Erika Borcel
Department of Psychobiology, Universidad Nacional de Educación a Distancia, Madrid, Spain
Ana Franco
Centro Nacional Biotecnología (CSIC), Universidad Autónoma de Madrid, Madrid, Spain
Carmen Sandi
Brain Mind Institute, Ecole Polytechnique Federale de Lausanne (EPFL), Switzerland
Luz M. Suárez, José M. Solís
Servicio de Neurobiología-Investigación, Hospital Ramón y Cajal, IRYCIS, Madrid, Spain
Eduardo D. Martín
Departamento de Ciencias Médicas, Universidad de Castilla-la Mancha, Albacete, Spain
Shizhong Li, Yongshuo Chen, Vladimir Berezin, Elisabeth Bock
Protein Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
Juncal Gonzalez-Soriano
Department of Anatomy, Faculty of Veterinary Medicine, Complutense University, Madrid, Spain

Corresponding Authors

Competing Interests

I have read the journal's policy and have the following conflicts. E. Bock and V. Berezin are shareholders of ENKAM Pharmaceuticals A/S, which owns the FGL peptide (less than 0.01% shares each). Nevertheless, this does not alter our adherence to all the PLoS Biology policies on sharing data and materials.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: SK CV CS JD JAE. Performed the experiments: EB VB SK CV EB CCS IPP SL YC AF LAN JGS PMS LMS JMS EM. Analyzed the data: SK CV LAN. Contributed reagents/materials/analysis tools: EB VB. Wrote the paper: SK CV JAE.