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Research Article

Multi-Cellular Rosettes in the Mouse Visceral Endoderm Facilitate the Ordered Migration of Anterior Visceral Endoderm Cells

  • Georgios Trichas equal contributor,

    equal contributor Contributed equally to this work with: Georgios Trichas, Aaron M. Smith

    Affiliation: Department of Physiology Anatomy & Genetics, University of Oxford, Oxford, United Kingdom

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  • Aaron M. Smith equal contributor,

    equal contributor Contributed equally to this work with: Georgios Trichas, Aaron M. Smith

    Affiliation: Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom

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  • Natalia White,

    Affiliation: Department of Physiology Anatomy & Genetics, University of Oxford, Oxford, United Kingdom

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  • Vivienne Wilkins,

    Affiliation: Department of Physiology Anatomy & Genetics, University of Oxford, Oxford, United Kingdom

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  • Tomoko Watanabe,

    Affiliation: Department of Physiology Anatomy & Genetics, University of Oxford, Oxford, United Kingdom

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  • Abigail Moore,

    Affiliation: Department of Physiology Anatomy & Genetics, University of Oxford, Oxford, United Kingdom

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  • Bradley Joyce,

    Affiliation: Department of Physiology Anatomy & Genetics, University of Oxford, Oxford, United Kingdom

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  • Jacintha Sugnaseelan,

    Affiliation: Department of Physiology Anatomy & Genetics, University of Oxford, Oxford, United Kingdom

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  • Tristan A. Rodriguez,

    Affiliation: Imperial College London, London, United Kingdom

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  • David Kay,

    Affiliation: Oxford University Computing Laboratory, Oxford, United Kingdom

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  • Ruth E. Baker,

    Affiliation: Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom

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  • Philip K. Maini,

    Affiliations: Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom, Oxford Centre for Integrative Systems Biology, Department of Biochemistry, Oxford, United Kingdom

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  • Shankar Srinivas mail

    shankar.srinivas@dpag.ox.ac.uk

    Affiliation: Department of Physiology Anatomy & Genetics, University of Oxford, Oxford, United Kingdom

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  • Published: February 07, 2012
  • DOI: 10.1371/journal.pbio.1001256

About the Authors

Georgios Trichas, Natalia White, Vivienne Wilkins, Tomoko Watanabe, Abigail Moore, Bradley Joyce, Jacintha Sugnaseelan, Shankar Srinivas
Department of Physiology Anatomy & Genetics, University of Oxford, Oxford, United Kingdom
Aaron M. Smith, Ruth E. Baker, Philip K. Maini
Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom
Tristan A. Rodriguez
Imperial College London, London, United Kingdom
David Kay
Oxford University Computing Laboratory, Oxford, United Kingdom
Philip K. Maini
Oxford Centre for Integrative Systems Biology, Department of Biochemistry, Oxford, United Kingdom

Corresponding Author

Email: shankar.srinivas@dpag.ox.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: SS PKM GT AS NW. Performed the experiments: GT AS NW VW BJ JS. Analyzed the data: GT AS NW TW AM BJ DK REB PKM SS. Contributed reagents/materials/analysis tools: TAR. Wrote the paper: SS AS PM GT.