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Research Article

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

  • Felix Margadant mail,

    felix@margadant.ch

    Affiliation: Research Centre of Excellence in Mechanobiology, National University of Singapore, Singapore

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  • Li Li Chew,

    Affiliation: Research Centre of Excellence in Mechanobiology, National University of Singapore, Singapore

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  • Xian Hu,

    Affiliation: Research Centre of Excellence in Mechanobiology, National University of Singapore, Singapore

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  • Hanry Yu,

    Affiliation: Research Centre of Excellence in Mechanobiology, National University of Singapore, Singapore

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  • Neil Bate,

    Affiliation: Department of Biochemistry, University of Leicester, Leicester, United Kingdom

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  • Xian Zhang,

    Affiliation: Department of Biological Sciences, Columbia University, New York, New York, United States of America

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  • Michael Sheetz

    Affiliation: Department of Biological Sciences, Columbia University, New York, New York, United States of America

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  • Published: December 20, 2011
  • DOI: 10.1371/journal.pbio.1001223

About the Authors

Felix Margadant, Li Li Chew, Xian Hu, Hanry Yu
Research Centre of Excellence in Mechanobiology, National University of Singapore, Singapore
Neil Bate
Department of Biochemistry, University of Leicester, Leicester, United Kingdom
Xian Zhang, Michael Sheetz
Department of Biological Sciences, Columbia University, New York, New York, United States of America

Corresponding Author

Email: felix@margadant.ch

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: FM LC XH XZ MS. Performed the experiments: LC XH XZ. Analyzed the data: FM MS NB LC. Contributed reagents/materials/analysis tools: MS HY. Wrote the paper: MS FM.