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Research Article

An Adhesion-Dependent Switch between Mechanisms That Determine Motile Cell Shape

  • Erin L. Barnhart,

    Affiliation: Department of Biochemistry and Howard Hughes Medical Institute, Stanford School of Medicine, Stanford, California, United States of America

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  • Kun-Chun Lee,

    Affiliation: Department of Mathematics, University of California, Davis, California, United States of America

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  • Kinneret Keren,

    Affiliation: Department of Physics and Russell Berrie Nanotechnology Institute, Technion – Israel Institute of Technology, Haifa, Israel

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  • Alex Mogilner,

    Affiliation: Department of Mathematics, University of California, Davis, California, United States of America

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  • Julie A. Theriot mail

    theriot@stanford.edu

    Affiliations: Department of Biochemistry and Howard Hughes Medical Institute, Stanford School of Medicine, Stanford, California, United States of America, Department of Microbiology and Immunology, Stanford School of Medicine, Stanford, California, United States of America

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  • Published: May 03, 2011
  • DOI: 10.1371/journal.pbio.1001059

About the Authors

Erin L. Barnhart, Julie A. Theriot
Department of Biochemistry and Howard Hughes Medical Institute, Stanford School of Medicine, Stanford, California, United States of America
Kun-Chun Lee, Alex Mogilner
Department of Mathematics, University of California, Davis, California, United States of America
Kinneret Keren
Department of Physics and Russell Berrie Nanotechnology Institute, Technion – Israel Institute of Technology, Haifa, Israel
Julie A. Theriot
Department of Microbiology and Immunology, Stanford School of Medicine, Stanford, California, United States of America

Corresponding Author

Email: theriot@stanford.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: ELB KK JAT. Performed the experiments: ELB. Analyzed the data: ELB KL AM. Wrote the paper: ELB KL AM JAT. Developed the model: AM KL ELB KK JAT. Performed model simulations: KL AM.