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Research Article

Neurosteroid Dehydroepiandrosterone Interacts with Nerve Growth Factor (NGF) Receptors, Preventing Neuronal Apoptosis

  • Iakovos Lazaridis equal contributor,

    equal contributor Contributed equally to this work with: Iakovos Lazaridis, Ioannis Charalampopoulos

    Affiliation: Department of Pharmacology, School of Medicine, University of Crete, Heraklion, Greece

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  • Ioannis Charalampopoulos equal contributor,

    equal contributor Contributed equally to this work with: Iakovos Lazaridis, Ioannis Charalampopoulos

    Affiliation: Department of Pharmacology, School of Medicine, University of Crete, Heraklion, Greece

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  • Vassilia-Ismini Alexaki,

    Affiliation: Experimental Endocrinology, School of Medicine, University of Crete, Heraklion, Greece

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  • Nicolaos Avlonitis,

    Affiliation: Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens, Greece

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  • Iosif Pediaditakis,

    Affiliation: Department of Pharmacology, School of Medicine, University of Crete, Heraklion, Greece

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  • Paschalis Efstathopoulos,

    Affiliation: Department of Pharmacology, School of Medicine, University of Crete, Heraklion, Greece

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  • Theodora Calogeropoulou,

    Affiliation: Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens, Greece

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  • Elias Castanas,

    Affiliation: Experimental Endocrinology, School of Medicine, University of Crete, Heraklion, Greece

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  • Achille Gravanis mail

    gravanis@med.uoc.gr

    Affiliation: Department of Pharmacology, School of Medicine, University of Crete, Heraklion, Greece

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  • Published: April 26, 2011
  • DOI: 10.1371/journal.pbio.1001051

About the Authors

Iakovos Lazaridis, Ioannis Charalampopoulos, Iosif Pediaditakis, Paschalis Efstathopoulos, Achille Gravanis
Department of Pharmacology, School of Medicine, University of Crete, Heraklion, Greece
Vassilia-Ismini Alexaki, Elias Castanas
Experimental Endocrinology, School of Medicine, University of Crete, Heraklion, Greece
Nicolaos Avlonitis, Theodora Calogeropoulou
Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens, Greece

Corresponding Author

Email: gravanis@med.uoc.gr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: IC EC AG. Performed the experiments: IL IC VIA IP PE NA. Analyzed the data: IL IC VIA EC AG. Contributed reagents/materials/analysis tools: NA TC. Wrote the paper: AG.