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Research Article

Chemotaxis: A Feedback-Based Computational Model Robustly Predicts Multiple Aspects of Real Cell Behaviour

  • Matthew P. Neilson,

    Affiliation: Cancer Research UK Beatson Institute, Glasgow, United Kingdom

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  • Douwe M. Veltman,

    Affiliation: Cancer Research UK Beatson Institute, Glasgow, United Kingdom

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  • Peter J. M. van Haastert,

    Affiliation: Department of Cell Biochemistry, University of Groningen, Groningen, The Netherlands

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  • Steven D. Webb,

    Affiliation: Department of Mathematics and Statistics, University of Strathclyde, Glasgow, United Kingdom

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  • John A. Mackenzie,

    Affiliation: Department of Mathematics and Statistics, University of Strathclyde, Glasgow, United Kingdom

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  • Robert H. Insall mail

    R.Insall@beatson.gla.ac.uk

    Affiliation: Cancer Research UK Beatson Institute, Glasgow, United Kingdom

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  • Published: May 17, 2011
  • DOI: 10.1371/journal.pbio.1000618

About the Authors

Matthew P. Neilson, Douwe M. Veltman, Robert H. Insall
Cancer Research UK Beatson Institute, Glasgow, United Kingdom
Peter J. M. van Haastert
Department of Cell Biochemistry, University of Groningen, Groningen, The Netherlands
Steven D. Webb, John A. Mackenzie
Department of Mathematics and Statistics, University of Strathclyde, Glasgow, United Kingdom

Corresponding Author

Email: R.Insall@beatson.gla.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: MPN PJMVH SDW JAM RHI. Performed the experiments: MPN DMV. Analyzed the data: MPN PJMVH JAM RHI. Contributed reagents/materials/analysis tools: DMV. Wrote the paper: MPN PJMVH SDW JAM RHI.