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Research Article

The Formation of the Bicoid Morphogen Gradient Requires Protein Movement from Anteriorly Localized mRNA

  • Shawn C. Little equal contributor,

    equal contributor Contributed equally to this work with: Shawn C. Little, Gašper Tkačik

    Affiliation: Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America

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  • Gašper Tkačik equal contributor,

    equal contributor Contributed equally to this work with: Shawn C. Little, Gašper Tkačik

    Affiliation: Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Thomas B. Kneeland,

    Affiliation: Joseph Henry Laboratories of Physics, Princeton University, Princeton, New Jersey, United States of America

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  • Eric F. Wieschaus,

    Affiliation: Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America

    X
  • Thomas Gregor mail

    tg2@princeton.edu

    Affiliations: Joseph Henry Laboratories of Physics, Princeton University, Princeton, New Jersey, United States of America, Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

    X
  • Published: March 01, 2011
  • DOI: 10.1371/journal.pbio.1000596

About the Authors

Shawn C. Little, Eric F. Wieschaus
Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
Gašper Tkačik
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Thomas B. Kneeland, Thomas Gregor
Joseph Henry Laboratories of Physics, Princeton University, Princeton, New Jersey, United States of America
Thomas Gregor
Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

Corresponding Author

Email: tg2@princeton.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: SCL GT TG. Performed the experiments: SCL TG. Analyzed the data: SCL GT TBK TG. Contributed reagents/materials/analysis tools: SCL GT TBK EFW TG. Wrote the paper: SCL GT EFW TG.