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Research Article

High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase

  • Tsuyoshi Hirota,

    Affiliations: Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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  • Jae Wook Lee,

    Affiliations: Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America, Department of Chemistry, The Scripps Research Institute, La Jolla, California, United States of America

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  • Warren G. Lewis,

    Affiliations: Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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  • Eric E. Zhang,

    Affiliations: Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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  • Ghislain Breton,

    Affiliation: Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America

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  • Xianzhong Liu,

    Affiliation: Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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  • Michael Garcia,

    Affiliation: Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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  • Eric C. Peters,

    Affiliation: Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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  • Jean-Pierre Etchegaray,

    Affiliation: Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • David Traver,

    Affiliation: Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America

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  • Peter G. Schultz,

    Affiliations: Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America, Department of Chemistry, The Scripps Research Institute, La Jolla, California, United States of America

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  • Steve A. Kay mail

    skay@ucsd.edu

    Affiliation: Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America

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  • Published: December 14, 2010
  • DOI: 10.1371/journal.pbio.1000559

About the Authors

Tsuyoshi Hirota, Warren G. Lewis, Eric E. Zhang, Ghislain Breton, David Traver, Steve A. Kay
Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America
Tsuyoshi Hirota, Jae Wook Lee, Warren G. Lewis, Eric E. Zhang, Xianzhong Liu, Michael Garcia, Eric C. Peters, Peter G. Schultz
Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
Jae Wook Lee, Peter G. Schultz
Department of Chemistry, The Scripps Research Institute, La Jolla, California, United States of America
Jean-Pierre Etchegaray
Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Corresponding Author

Email: skay@ucsd.edu

Competing Interests

SAK is a SAB member of Reset Therapeutics.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: TH JWL PGS SAK. Performed the experiments: TH JWL WGL EEZ GB XL MG ECP. Analyzed the data: TH WGL. Contributed reagents/materials/analysis tools: TH JWL WGL GB JPE DT. Wrote the paper: TH SAK.