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Research Article

The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis

  • Tokameh Mahmoudi mail,

    t.mahmoudi@erasmusmc.nl

    Affiliation: Hubrecht Institute and University Medical Centre Utrecht, Utrecht, The Netherlands

    Current address: Erasmus University Medical Center, Department of Biochemistry, Rotterdam, The Netherlands

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  • Sylvia F. Boj equal contributor,

    equal contributor Contributed equally to this work with: Sylvia F. Boj, Pantelis Hatzis

    Affiliation: Hubrecht Institute and University Medical Centre Utrecht, Utrecht, The Netherlands

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  • Pantelis Hatzis equal contributor,

    equal contributor Contributed equally to this work with: Sylvia F. Boj, Pantelis Hatzis

    Affiliation: Hubrecht Institute and University Medical Centre Utrecht, Utrecht, The Netherlands

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  • Vivian S. W. Li,

    Affiliation: Hubrecht Institute and University Medical Centre Utrecht, Utrecht, The Netherlands

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  • Nadia Taouatas,

    Affiliation: Biomolecular Mass Spectrometry and Proteomics Group, Utrecht University, Utrecht, The Netherlands

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  • Robert G. J. Vries,

    Affiliation: Hubrecht Institute and University Medical Centre Utrecht, Utrecht, The Netherlands

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  • Hans Teunissen,

    Affiliation: Hubrecht Institute and University Medical Centre Utrecht, Utrecht, The Netherlands

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  • Harry Begthel,

    Affiliation: Hubrecht Institute and University Medical Centre Utrecht, Utrecht, The Netherlands

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  • Jeroen Korving,

    Affiliation: Hubrecht Institute and University Medical Centre Utrecht, Utrecht, The Netherlands

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  • Shabaz Mohammed,

    Affiliation: Biomolecular Mass Spectrometry and Proteomics Group, Utrecht University, Utrecht, The Netherlands

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  • Albert J. R. Heck,

    Affiliation: Biomolecular Mass Spectrometry and Proteomics Group, Utrecht University, Utrecht, The Netherlands

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  • Hans Clevers

    Affiliation: Hubrecht Institute and University Medical Centre Utrecht, Utrecht, The Netherlands

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  • Published: November 16, 2010
  • DOI: 10.1371/journal.pbio.1000539

About the Authors

Tokameh Mahmoudi, Sylvia F. Boj, Pantelis Hatzis, Vivian S. W. Li, Robert G. J. Vries, Hans Teunissen, Harry Begthel, Jeroen Korving, Hans Clevers
Hubrecht Institute and University Medical Centre Utrecht, Utrecht, The Netherlands
Nadia Taouatas, Shabaz Mohammed, Albert J. R. Heck
Biomolecular Mass Spectrometry and Proteomics Group, Utrecht University, Utrecht, The Netherlands

Corresponding Author

Email: t.mahmoudi@erasmusmc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: TM SM AJRH HC. Performed the experiments: TM SFB PH VSWL NT RGJV HT HB JK. Analyzed the data: TM SFB VSWL. Contributed reagents/materials/analysis tools: TM HC. Wrote the paper: TM HC.