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Research Article

The DNA Methylome of Human Peripheral Blood Mononuclear Cells

  • Yingrui Li equal contributor,

    equal contributor Contributed equally to this work with: Yingrui Li, Jingde Zhu, Geng Tian, Ning Li, Qibin Li

    Affiliation: BGI-Shenzhen, Shenzhen, Guangdong, China

    X
  • Jingde Zhu equal contributor,

    equal contributor Contributed equally to this work with: Yingrui Li, Jingde Zhu, Geng Tian, Ning Li, Qibin Li

    Affiliations: Cancer Epigenetics and Gene Therapy Program, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China, Epigentic Laboratory, Bio-X Center, Shanghai JiaoTong University, Shanghai, China

    X
  • Geng Tian equal contributor,

    equal contributor Contributed equally to this work with: Yingrui Li, Jingde Zhu, Geng Tian, Ning Li, Qibin Li

    Affiliations: Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China, The Graduate University of Chinese Academy of Sciences, Beijing, China, BGI-Shenzhen, Shenzhen, Guangdong, China

    X
  • Ning Li equal contributor,

    equal contributor Contributed equally to this work with: Yingrui Li, Jingde Zhu, Geng Tian, Ning Li, Qibin Li

    Affiliation: BGI-Shenzhen, Shenzhen, Guangdong, China

    X
  • Qibin Li equal contributor,

    equal contributor Contributed equally to this work with: Yingrui Li, Jingde Zhu, Geng Tian, Ning Li, Qibin Li

    Affiliation: BGI-Shenzhen, Shenzhen, Guangdong, China

    X
  • Mingzhi Ye,

    Affiliation: BGI-Shenzhen, Shenzhen, Guangdong, China

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  • Hancheng Zheng,

    Affiliation: BGI-Shenzhen, Shenzhen, Guangdong, China

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  • Jian Yu,

    Affiliation: Cancer Epigenetics and Gene Therapy Program, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China

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  • Honglong Wu,

    Affiliation: BGI-Shenzhen, Shenzhen, Guangdong, China

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  • Jihua Sun,

    Affiliation: BGI-Shenzhen, Shenzhen, Guangdong, China

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  • Hongyu Zhang,

    Affiliation: Cancer Epigenetics and Gene Therapy Program, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China

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  • Quan Chen,

    Affiliation: BGI-Shenzhen, Shenzhen, Guangdong, China

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  • Ruibang Luo,

    Affiliations: BGI-Shenzhen, Shenzhen, Guangdong, China, School of Bioscience and Biotechnology, South China University of Technology, Guangzhou, China

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  • Minfeng Chen,

    Affiliation: BGI-Shenzhen, Shenzhen, Guangdong, China

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  • Yinghua He,

    Affiliation: Cancer Epigenetics and Gene Therapy Program, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China

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  • Xin Jin,

    Affiliations: BGI-Shenzhen, Shenzhen, Guangdong, China, School of Bioscience and Biotechnology, South China University of Technology, Guangzhou, China

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  • Qinghui Zhang,

    Affiliation: BGI-Shenzhen, Shenzhen, Guangdong, China

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  • Chang Yu,

    Affiliation: BGI-Shenzhen, Shenzhen, Guangdong, China

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  • Guangyu Zhou,

    Affiliation: BGI-Shenzhen, Shenzhen, Guangdong, China

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  • Jinfeng Sun,

    Affiliation: Cancer Epigenetics and Gene Therapy Program, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China

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  • Yebo Huang,

    Affiliation: BGI-Shenzhen, Shenzhen, Guangdong, China

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  • Huisong Zheng,

    Affiliation: BGI-Shenzhen, Shenzhen, Guangdong, China

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  • Hongzhi Cao,

    Affiliation: BGI-Shenzhen, Shenzhen, Guangdong, China

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  • Xiaoyu Zhou,

    Affiliation: Cancer Epigenetics and Gene Therapy Program, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China

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  • Shicheng Guo,

    Affiliation: Cancer Epigenetics and Gene Therapy Program, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China

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  • Xueda Hu,

    Affiliation: BGI-Shenzhen, Shenzhen, Guangdong, China

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  • Xin Li,

    Affiliation: Kunming Institute of Zoology, Chinese Academy of Sciences, Yunnan, China

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  • Karsten Kristiansen,

    Affiliation: Department of Biology, University of Copenhagen, Copenhagen, Denmark

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  • Lars Bolund,

    Affiliations: BGI-Shenzhen, Shenzhen, Guangdong, China, Institute of Human Genetics, University of Aarhus, Aarhus, Denmark

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  • Jiujin Xu,

    Affiliation: Institute of Genetics and Developmental Biology, Chinese Academy of Human Sciences, Beijing, China

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  • Wen Wang,

    Affiliation: Kunming Institute of Zoology, Chinese Academy of Sciences, Yunnan, China

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  • Huanming Yang,

    Affiliation: BGI-Shenzhen, Shenzhen, Guangdong, China

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  • Jian Wang,

    Affiliation: BGI-Shenzhen, Shenzhen, Guangdong, China

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  • Ruiqiang Li,

    Affiliation: BGI-Shenzhen, Shenzhen, Guangdong, China

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  • Stephan Beck mail,

    zhangxq@genomics.org.cn (XZ); wangj@genomics.org.cn (JW); s.beck@ucl.ac.uk (SB)

    Affiliation: UCL Cancer Institute, University College London, London, United Kingdom

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  • Jun Wang mail,

    zhangxq@genomics.org.cn (XZ); wangj@genomics.org.cn (JW); s.beck@ucl.ac.uk (SB)

    Affiliations: BGI-Shenzhen, Shenzhen, Guangdong, China, Department of Biology, University of Copenhagen, Copenhagen, Denmark

    X
  • Xiuqing Zhang mail

    zhangxq@genomics.org.cn (XZ); wangj@genomics.org.cn (JW); s.beck@ucl.ac.uk (SB)

    Affiliation: BGI-Shenzhen, Shenzhen, Guangdong, China

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  • Published: November 09, 2010
  • DOI: 10.1371/journal.pbio.1000533

About the Authors

Yingrui Li, Geng Tian, Ning Li, Qibin Li, Mingzhi Ye, Hancheng Zheng, Honglong Wu, Jihua Sun, Quan Chen, Ruibang Luo, Minfeng Chen, Xin Jin, Qinghui Zhang, Chang Yu, Guangyu Zhou, Yebo Huang, Huisong Zheng, Hongzhi Cao, Xueda Hu, Lars Bolund, Huanming Yang, Jian Wang, Ruiqiang Li, Jun Wang, Xiuqing Zhang
BGI-Shenzhen, Shenzhen, Guangdong, China
Jingde Zhu, Jian Yu, Hongyu Zhang, Yinghua He, Jinfeng Sun, Xiaoyu Zhou, Shicheng Guo
Cancer Epigenetics and Gene Therapy Program, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China
Jingde Zhu
Epigentic Laboratory, Bio-X Center, Shanghai JiaoTong University, Shanghai, China
Geng Tian
Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
Geng Tian
The Graduate University of Chinese Academy of Sciences, Beijing, China
Ruibang Luo, Xin Jin
School of Bioscience and Biotechnology, South China University of Technology, Guangzhou, China
Xin Li, Wen Wang
Kunming Institute of Zoology, Chinese Academy of Sciences, Yunnan, China
Karsten Kristiansen, Jun Wang
Department of Biology, University of Copenhagen, Copenhagen, Denmark
Lars Bolund
Institute of Human Genetics, University of Aarhus, Aarhus, Denmark
Jiujin Xu
Institute of Genetics and Developmental Biology, Chinese Academy of Human Sciences, Beijing, China
Stephan Beck
UCL Cancer Institute, University College London, London, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: JZ GT WW HY JW SB JW XZ. Performed the experiments: JZ GT MY JY JS HZ MC YH QZ JS YH HZ XZ SG XH LB JX XZ. Analyzed the data: YL NL QL HZ HW RL XJ GZ HC KK RL SB JW. Contributed reagents/materials/analysis tools: YL JZ NL QL HZ QC CY RL XZ. Wrote the paper: YL XL SB JW.