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Research Article

Emergence of Noise-Induced Oscillations in the Central Circadian Pacemaker

  • Caroline H. Ko equal contributor,

    equal contributor Contributed equally to this work with: Caroline H. Ko, Yujiro R. Yamada, David K. Welsh

    Affiliations: Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America, Department of Psychology, University of Toronto, Toronto, Ontario, Canada

    Current address: Department of Chemistry, Northwestern University, Evanston, Illinois, United States of America

    X
  • Yujiro R. Yamada equal contributor,

    equal contributor Contributed equally to this work with: Caroline H. Ko, Yujiro R. Yamada, David K. Welsh

    Affiliation: Department of Mathematics, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • David K. Welsh equal contributor,

    equal contributor Contributed equally to this work with: Caroline H. Ko, Yujiro R. Yamada, David K. Welsh

    Affiliations: Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, California, United States of America, Department of Psychiatry, University of California, San Diego, La Jolla, California, United States of America, Veterans Affairs San Diego Healthcare System, San Diego, California, United States of America

    X
  • Ethan D. Buhr,

    Affiliation: Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America

    Current address: Department of Ophthalmology, University of Washington, Seattle, Washington, United States of America

    X
  • Andrew C. Liu,

    Affiliation: Genomics Institute of Novartis Research Foundation, San Diego, California, United States of America

    Current address: Department of Biology, University of Memphis, Memphis, Tennessee, United States of America

    X
  • Eric E. Zhang,

    Affiliation: Genomics Institute of Novartis Research Foundation, San Diego, California, United States of America

    X
  • Martin R. Ralph,

    Affiliations: Department of Psychology, University of Toronto, Toronto, Ontario, Canada, Center for Biological Timing and Cognition, University of Toronto, Toronto, Ontario, Canada

    X
  • Steve A. Kay,

    Affiliation: Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, California, United States of America

    X
  • Daniel B. Forger,

    Affiliations: Department of Mathematics, University of Michigan, Ann Arbor, Michigan, United States of America, Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Joseph S. Takahashi mail

    Joseph.Takahashi@UTSouthwestern.edu

    Affiliations: Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

    X
  • Published: October 12, 2010
  • DOI: 10.1371/journal.pbio.1000513

About the Authors

Caroline H. Ko, Joseph S. Takahashi
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Caroline H. Ko, Ethan D. Buhr, Joseph S. Takahashi
Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America
Caroline H. Ko, Martin R. Ralph
Department of Psychology, University of Toronto, Toronto, Ontario, Canada
Yujiro R. Yamada, Daniel B. Forger
Department of Mathematics, University of Michigan, Ann Arbor, Michigan, United States of America
David K. Welsh, Steve A. Kay
Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, California, United States of America
David K. Welsh
Department of Psychiatry, University of California, San Diego, La Jolla, California, United States of America
David K. Welsh
Veterans Affairs San Diego Healthcare System, San Diego, California, United States of America
Andrew C. Liu, Eric E. Zhang
Genomics Institute of Novartis Research Foundation, San Diego, California, United States of America
Martin R. Ralph
Center for Biological Timing and Cognition, University of Toronto, Toronto, Ontario, Canada
Daniel B. Forger
Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America
Joseph S. Takahashi
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Corresponding Author

Email: Joseph.Takahashi@UTSouthwestern.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: CHK YRY DKW SAK DBF JST. Performed the experiments: CHK YRY DKW EDB ACL EEZ DBF. Analyzed the data: CHK YRY DKW EDB ACL EEZ DBF JST. Contributed reagents/materials/analysis tools: MRR SAK. Wrote the paper: CHK YRY DBF JST.