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Research Article

Protein Evolution by Molecular Tinkering: Diversification of the Nuclear Receptor Superfamily from a Ligand-Dependent Ancestor

  • Jamie T. Bridgham,

    Affiliations: Howard Hughes Medical Institute, Eugene, Oregon, United States of America, Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon, United States of America

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  • Geeta N. Eick,

    Affiliation: Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon, United States of America

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  • Claire Larroux,

    Affiliation: School of Biological Sciences, University of Queensland, Brisbane, Australia

    Current address: Department of Earth & Environmental Sciences, Ludwig-Maximilians-University, Munich, Germany

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  • Kirti Deshpande,

    Affiliation: Biochemistry Department, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Michael J. Harms,

    Affiliation: Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon, United States of America

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  • Marie E. A. Gauthier,

    Affiliation: School of Biological Sciences, University of Queensland, Brisbane, Australia

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  • Eric A. Ortlund,

    Affiliation: Biochemistry Department, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Bernard M. Degnan,

    Affiliation: School of Biological Sciences, University of Queensland, Brisbane, Australia

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  • Joseph W. Thornton mail

    joet@uoregon.edu

    Affiliations: Howard Hughes Medical Institute, Eugene, Oregon, United States of America, Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon, United States of America

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  • Published: October 05, 2010
  • DOI: 10.1371/journal.pbio.1000497

About the Authors

Jamie T. Bridgham, Joseph W. Thornton
Howard Hughes Medical Institute, Eugene, Oregon, United States of America
Jamie T. Bridgham, Geeta N. Eick, Michael J. Harms, Joseph W. Thornton
Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon, United States of America
Claire Larroux, Marie E. A. Gauthier, Bernard M. Degnan
School of Biological Sciences, University of Queensland, Brisbane, Australia
Kirti Deshpande, Eric A. Ortlund
Biochemistry Department, Emory University School of Medicine, Atlanta, Georgia, United States of America

Corresponding Author

Email: joet@uoregon.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: JTB EO BMD JWT. Performed the experiments: JTB GNE CL KD MJH MG EO JWT. Analyzed the data: JTB GNE CL KD MJH MG EO BMD JWT. Wrote the paper: JWT.