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Research Article

A Senescence-Like Cell-Cycle Arrest Occurs During Megakaryocytic Maturation: Implications for Physiological and Pathological Megakaryocytic Proliferation

  • Rodolphe Besancenot equal contributor,

    equal contributor Contributed equally to this work with: Rodolphe Besancenot, Ronan Chaligné

    Affiliations: INSERM, U790, Institut Gustave Roussy, Villejuif, France, Université Paris XI, IFR54, Institut Gustave Roussy, Villejuif, France

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  • Ronan Chaligné equal contributor,

    equal contributor Contributed equally to this work with: Rodolphe Besancenot, Ronan Chaligné

    Affiliations: INSERM, U790, Institut Gustave Roussy, Villejuif, France, Université Paris XI, IFR54, Institut Gustave Roussy, Villejuif, France

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  • Carole Tonetti,

    Affiliation: AP-HP, Université Paris XII, Laboratoire d'Hématologie, PRB Cellulothèque hématologie, Hôpital Henri Mondor, Créteil, France

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  • Florence Pasquier,

    Affiliations: INSERM, U790, Institut Gustave Roussy, Villejuif, France, Université Paris XI, IFR54, Institut Gustave Roussy, Villejuif, France

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  • Caroline Marty,

    Affiliations: INSERM, U790, Institut Gustave Roussy, Villejuif, France, Université Paris XI, IFR54, Institut Gustave Roussy, Villejuif, France

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  • Yann Lécluse,

    Affiliation: Université Paris XI, IFR54, Institut Gustave Roussy, Villejuif, France

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  • William Vainchenker,

    Affiliations: INSERM, U790, Institut Gustave Roussy, Villejuif, France, Université Paris XI, IFR54, Institut Gustave Roussy, Villejuif, France

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  • Stefan N. Constantinescu,

    Affiliation: Ludwig Institute for Cancer Research, Brussels, Belgium

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  • Stéphane Giraudier mail

    stephane.giraudier@hmn.aphp.fr

    Affiliations: INSERM, U790, Institut Gustave Roussy, Villejuif, France, AP-HP, Université Paris XII, Laboratoire d'Hématologie, PRB Cellulothèque hématologie, Hôpital Henri Mondor, Créteil, France

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  • Published: September 07, 2010
  • DOI: 10.1371/journal.pbio.1000476

About the Authors

Rodolphe Besancenot, Ronan Chaligné, Florence Pasquier, Caroline Marty, William Vainchenker, Stéphane Giraudier
INSERM, U790, Institut Gustave Roussy, Villejuif, France
Rodolphe Besancenot, Ronan Chaligné, Florence Pasquier, Caroline Marty, Yann Lécluse, William Vainchenker
Université Paris XI, IFR54, Institut Gustave Roussy, Villejuif, France
Carole Tonetti, Stéphane Giraudier
AP-HP, Université Paris XII, Laboratoire d'Hématologie, PRB Cellulothèque hématologie, Hôpital Henri Mondor, Créteil, France
Stefan N. Constantinescu
Ludwig Institute for Cancer Research, Brussels, Belgium

Corresponding Author

Email: stephane.giraudier@hmn.aphp.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: RB RC WV SNC SG. Performed the experiments: RB RC CT FP CM YL. Analyzed the data: RB RC CT FP CM WV SG. Contributed reagents/materials/analysis tools: RB RC FP CM YL SG. Wrote the paper: RB RC WV SNC SG.