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Research Article

IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition

  • Eduardo R. Ropelle,

    Affiliation: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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  • Marcelo B. Flores,

    Affiliation: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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  • Dennys E. Cintra,

    Affiliation: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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  • Guilherme Z. Rocha,

    Affiliation: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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  • José R. Pauli,

    Affiliation: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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  • Joseane Morari,

    Affiliation: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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  • Claudio T. de Souza,

    Affiliation: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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  • Juliana C. Moraes,

    Affiliation: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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  • Patrícia O. Prada,

    Affiliation: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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  • Dioze Guadagnini,

    Affiliation: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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  • Rodrigo M. Marin,

    Affiliation: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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  • Alexandre G. Oliveira,

    Affiliation: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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  • Taize M. Augusto,

    Affiliation: Department of Anatomy, Cell Biology, Physiology and Biophysics, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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  • Hernandes F. Carvalho,

    Affiliation: Department of Anatomy, Cell Biology, Physiology and Biophysics, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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  • Lício A. Velloso,

    Affiliation: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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  • Mario J. A. Saad,

    Affiliation: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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  • José B. C. Carvalheira mail

    carvalheirajbc@uol.com.br

    Affiliation: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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  • Published: August 24, 2010
  • DOI: 10.1371/journal.pbio.1000465

About the Authors

Eduardo R. Ropelle, Marcelo B. Flores, Dennys E. Cintra, Guilherme Z. Rocha, José R. Pauli, Joseane Morari, Claudio T. de Souza, Juliana C. Moraes, Patrícia O. Prada, Dioze Guadagnini, Rodrigo M. Marin, Alexandre G. Oliveira, Lício A. Velloso, Mario J. A. Saad, José B. C. Carvalheira
Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
Taize M. Augusto, Hernandes F. Carvalho
Department of Anatomy, Cell Biology, Physiology and Biophysics, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

Corresponding Author

Email: carvalheirajbc@uol.com.br

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: ERR JBC. Performed the experiments: ERR MBF DEC GZR JRP JM CTDS JCM POP DG RMM AGO TMA HFC. Analyzed the data: ERR DEC LAV MJS JBC. Wrote the paper: ERR JBC.