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Research Article

Quantitative Analysis of the Drosophila Segmentation Regulatory Network Using Pattern Generating Potentials

  • Majid Kazemian equal contributor,

    equal contributor Contributed equally to this work with: Majid Kazemian, Charles Blatti

    Affiliation: Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana-Champaign, Illinois, United States of America

    X
  • Charles Blatti equal contributor,

    equal contributor Contributed equally to this work with: Majid Kazemian, Charles Blatti

    Affiliation: Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana-Champaign, Illinois, United States of America

    X
  • Adam Richards,

    Affiliations: Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Michael McCutchan,

    Affiliation: Center for Evolutionary Functional Genomics, Biodesign Institute, Arizona State University, Tempe, Arizona, United States of America

    X
  • Noriko Wakabayashi-Ito,

    Affiliations: Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Ann S. Hammonds,

    Affiliation: Department of Genome Dynamics, Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

    X
  • Susan E. Celniker,

    Affiliation: Department of Genome Dynamics, Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

    X
  • Sudhir Kumar,

    Affiliation: Center for Evolutionary Functional Genomics, Biodesign Institute, Arizona State University, Tempe, Arizona, United States of America

    X
  • Scot A. Wolfe,

    Affiliations: Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Michael H. Brodsky mail,

    sinhas@illinois.edu (SS); Michael.brodsky@umassmed.edu (MHB)

    Affiliations: Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Saurabh Sinha mail

    sinhas@illinois.edu (SS); Michael.brodsky@umassmed.edu (MHB)

    Affiliations: Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana-Champaign, Illinois, United States of America, Institute of Genomic Biology, University of Illinois at Urbana-Champaign, Urbana-Champaign, Illinois, United States of America

    X
  • Published: August 17, 2010
  • DOI: 10.1371/journal.pbio.1000456

About the Authors

Majid Kazemian, Charles Blatti, Saurabh Sinha
Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana-Champaign, Illinois, United States of America
Adam Richards, Noriko Wakabayashi-Ito, Scot A. Wolfe, Michael H. Brodsky
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Adam Richards, Noriko Wakabayashi-Ito, Michael H. Brodsky
Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Michael McCutchan, Sudhir Kumar
Center for Evolutionary Functional Genomics, Biodesign Institute, Arizona State University, Tempe, Arizona, United States of America
Ann S. Hammonds, Susan E. Celniker
Department of Genome Dynamics, Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
Scot A. Wolfe
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Saurabh Sinha
Institute of Genomic Biology, University of Illinois at Urbana-Champaign, Urbana-Champaign, Illinois, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: MK CB SAW MHB SS. Performed the experiments: MK CB NWI ASH MHB. Analyzed the data: MK CB SS. Contributed reagents/materials/analysis tools: AR MM SEC SK. Wrote the paper: SAW MHB SS.