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Research Article

Robust Target Gene Discovery through Transcriptome Perturbations and Genome-Wide Enhancer Predictions in Drosophila Uncovers a Regulatory Basis for Sensory Specification

  • Stein Aerts mail,

    stein.aerts@med.kuleuven.be (SA); bassem.hassan@cme.vib-kuleuven.be (BAH)

    Affiliations: Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium, Laboratory of Computational Biology, Katholieke Universiteit (K.U.) Leuven, Leuven, Belgium, Center for Human Genetics, K.U. Leuven, Leuven, Belgium, Doctoral Program in Molecular and Developmental Genetics, K.U. Leuven Group Biomedicine, Leuven, Belgium

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  • Xiao-Jiang Quan,

    Affiliations: Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium, Center for Human Genetics, K.U. Leuven, Leuven, Belgium

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  • Annelies Claeys,

    Affiliations: Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium, Center for Human Genetics, K.U. Leuven, Leuven, Belgium

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  • Marina Naval Sanchez,

    Affiliations: Laboratory of Computational Biology, Katholieke Universiteit (K.U.) Leuven, Leuven, Belgium, Doctoral Program in Molecular and Developmental Genetics, K.U. Leuven Group Biomedicine, Leuven, Belgium

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  • Phillip Tate,

    Affiliations: Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium, Center for Human Genetics, K.U. Leuven, Leuven, Belgium

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  • Jiekun Yan,

    Affiliations: Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium, Center for Human Genetics, K.U. Leuven, Leuven, Belgium

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  • Bassem A. Hassan mail

    stein.aerts@med.kuleuven.be (SA); bassem.hassan@cme.vib-kuleuven.be (BAH)

    Affiliations: Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium, Center for Human Genetics, K.U. Leuven, Leuven, Belgium, Doctoral Program in Molecular and Developmental Genetics, K.U. Leuven Group Biomedicine, Leuven, Belgium

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  • Published: July 27, 2010
  • DOI: 10.1371/journal.pbio.1000435

About the Authors

Stein Aerts, Xiao-Jiang Quan, Annelies Claeys, Phillip Tate, Jiekun Yan, Bassem A. Hassan
Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium
Stein Aerts, Marina Naval Sanchez
Laboratory of Computational Biology, Katholieke Universiteit (K.U.) Leuven, Leuven, Belgium
Stein Aerts, Xiao-Jiang Quan, Annelies Claeys, Phillip Tate, Jiekun Yan, Bassem A. Hassan
Center for Human Genetics, K.U. Leuven, Leuven, Belgium
Stein Aerts, Marina Naval Sanchez, Bassem A. Hassan
Doctoral Program in Molecular and Developmental Genetics, K.U. Leuven Group Biomedicine, Leuven, Belgium

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: SA BAH. Performed the experiments: SA XJQ AC PT JY. Analyzed the data: SA XJQ MNS BAH. Wrote the paper: SA BAH.