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Research Article

The Role of Spatially Controlled Cell Proliferation in Limb Bud Morphogenesis

  • Bernd Boehm,

    Affiliation: EMBL-CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, Barcelona, Spain

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  • Henrik Westerberg,

    Affiliation: EMBL-CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, Barcelona, Spain

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  • Gaja Lesnicar-Pucko,

    Affiliation: EMBL-CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, Barcelona, Spain

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  • Sahdia Raja,

    Affiliations: EMBL-CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, Barcelona, Spain, MRC Human Genetics Unit, Edinburgh, Scotland, United Kingdom

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  • Michael Rautschka,

    Affiliation: EMBL-CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, Barcelona, Spain

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  • James Cotterell,

    Affiliations: EMBL-CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, Barcelona, Spain, MRC Human Genetics Unit, Edinburgh, Scotland, United Kingdom

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  • Jim Swoger,

    Affiliation: EMBL-CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, Barcelona, Spain

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  • James Sharpe mail

    james.sharpe@crg.es

    Affiliations: EMBL-CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, Barcelona, Spain, ICREA Professor, Centre for Genomic Regulation (CRG), UPF, Barcelona, Spain

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  • Published: July 13, 2010
  • DOI: 10.1371/journal.pbio.1000420

About the Authors

Bernd Boehm, Henrik Westerberg, Gaja Lesnicar-Pucko, Sahdia Raja, Michael Rautschka, James Cotterell, Jim Swoger, James Sharpe
EMBL-CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, Barcelona, Spain
Sahdia Raja, James Cotterell
MRC Human Genetics Unit, Edinburgh, Scotland, United Kingdom
James Sharpe
ICREA Professor, Centre for Genomic Regulation (CRG), UPF, Barcelona, Spain

Corresponding Author

Email: james.sharpe@crg.es

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: JS. Performed the experiments: BRB GLP SR JC. Analyzed the data: BRB JC JS. Contributed reagents/materials/analysis tools: CHW SR MR. Wrote the paper: BRB JS.