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Research Article

Cortical Overexpression of Neuronal Calcium Sensor-1 Induces Functional Plasticity in Spinal Cord Following Unilateral Pyramidal Tract Injury in Rat

  • Ping K. Yip mail,

    ping.yip@kcl.ac.uk

    Affiliation: Neurorestoration Group, Wolfson CARD, King's College London, Guy's Campus, London, United Kingdom

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  • Liang-Fong Wong,

    Affiliation: Henry Wellcome LINE, Dorothy Hodgkin Building, Bristol University, Bristol, United Kingdom

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  • Thomas A. Sears,

    Affiliation: Neurorestoration Group, Wolfson CARD, King's College London, Guy's Campus, London, United Kingdom

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  • Rafael J. Yáñez-Muñoz,

    Affiliation: School of Biological Sciences, Royal Holloway-University of London, Egham, Surrey, United Kingdom

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  • Stephen B. McMahon

    Affiliation: Neurorestoration Group, Wolfson CARD, King's College London, Guy's Campus, London, United Kingdom

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  • Published: June 22, 2010
  • DOI: 10.1371/journal.pbio.1000399

About the Authors

Ping K. Yip, Thomas A. Sears, Stephen B. McMahon
Neurorestoration Group, Wolfson CARD, King's College London, Guy's Campus, London, United Kingdom
Liang-Fong Wong
Henry Wellcome LINE, Dorothy Hodgkin Building, Bristol University, Bristol, United Kingdom
Rafael J. Yáñez-Muñoz
School of Biological Sciences, Royal Holloway-University of London, Egham, Surrey, United Kingdom

Corresponding Author

Email: ping.yip@kcl.ac.uk

Competing Interests

The authors Ping K. Yip, Liang-Fong Wong and Stephen McMahon would like to declare competing financial interests in relation to this work. There is a patent application submitted by King's College London and Oxford BioMedica Ltd entitled: System for delivering neuronal calcium sensor-1 (NCS-1) (International Application No.: PCT/GB2006/003367). The abstract on the application is: The present invention provides a system capable of delivering neuronal calcium sensor-1 (NCS-1), or a nucleotide sequence encoding NCS-1 to a target cell, for promoting neurite outgrowth. The system may be used in the manufacture of a pharmaceutical composition for the treatment of a condition such as spinal cord injury.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: PKY. Performed the experiments: PKY TAS. Analyzed the data: PKY TAS. Contributed reagents/materials/analysis tools: PKY LFW RJYM. Wrote the paper: PKY TAS SBM.