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Research Article

Dysregulation of the Norepinephrine Transporter Sustains Cortical Hypodopaminergia and Schizophrenia-Like Behaviors in Neuronal Rictor Null Mice

  • Michael A. Siuta equal contributor,

    equal contributor Contributed equally to this work with: Michael A. Siuta, Sabrina D. Robertson

    Affiliation: Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Sabrina D. Robertson equal contributor,

    equal contributor Contributed equally to this work with: Michael A. Siuta, Sabrina D. Robertson

    Affiliation: Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Heidi Kocalis,

    Affiliation: Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Christine Saunders,

    Affiliation: Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Paul J. Gresch,

    Affiliation: Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Vivek Khatri,

    Affiliation: Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Chiyo Shiota,

    Affiliations: Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Surgery, Children's Hospital of Pittsburgh of UPMC, and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • J. Philip Kennedy,

    Affiliation: Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Craig W. Lindsley,

    Affiliation: Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Lynette C. Daws,

    Affiliation: Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas, United States of America

    X
  • Daniel B. Polley,

    Affiliations: Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Hearing and Speech Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Jeremy Veenstra-Vanderweele,

    Affiliations: Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Gregg D. Stanwood,

    Affiliations: Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Mark A. Magnuson,

    Affiliation: Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Kevin D. Niswender mail,

    aurelio.galli@vanderbilt.edu (AG); kevin.niswender@vanderbilt.edu (KDN)

    Affiliations: Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America, Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    These authors also contributed equally to this work.

    X
  • Aurelio Galli mail

    aurelio.galli@vanderbilt.edu (AG); kevin.niswender@vanderbilt.edu (KDN)

    Affiliations: Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    These authors also contributed equally to this work.

    X
  • Published: June 08, 2010
  • DOI: 10.1371/journal.pbio.1000393

About the Authors

Michael A. Siuta, Sabrina D. Robertson, Jeremy Veenstra-Vanderweele, Aurelio Galli
Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Heidi Kocalis, Chiyo Shiota, Mark A. Magnuson, Kevin D. Niswender, Aurelio Galli
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Christine Saunders, Paul J. Gresch, J. Philip Kennedy, Craig W. Lindsley, Jeremy Veenstra-Vanderweele, Gregg D. Stanwood
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Vivek Khatri, Daniel B. Polley, Jeremy Veenstra-Vanderweele, Gregg D. Stanwood
Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Chiyo Shiota
Department of Surgery, Children's Hospital of Pittsburgh of UPMC, and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
Lynette C. Daws
Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas, United States of America
Daniel B. Polley
Department of Hearing and Speech Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Jeremy Veenstra-Vanderweele
Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Kevin D. Niswender
Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America
Kevin D. Niswender
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: MAS SDR CS VK DBP JVV GDS KDN AG. Performed the experiments: MAS SDR HK CS PJG VK LCD JVV GDS. Analyzed the data: MAS SDR HK CS PJG VK DBP JVV GDS. Contributed reagents/materials/analysis tools: HK CS JPK CWL MAM. Wrote the paper: MAS SDR KDN AG.