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Research Article

Dynamic Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by the Morphogen Sonic Hedgehog

  • Eric Dessaud equal contributor,

    equal contributor Contributed equally to this work with: Eric Dessaud, Noriaki Sasai

    Affiliation: Developmental Neurobiology, MRC-National Institute for Medical Research, London, United Kingdom

    X
  • Vanessa Ribes,

    Affiliation: Developmental Neurobiology, MRC-National Institute for Medical Research, London, United Kingdom

    X
  • Nikolaos Balaskas,

    Affiliation: Developmental Neurobiology, MRC-National Institute for Medical Research, London, United Kingdom

    X
  • Lin Lin Yang,

    Affiliation: Department of Neurobiology, Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

    X
  • Alessandra Pierani,

    Affiliation: Institut Jacques Monod, Université Paris Diderot, Program of Development and Neurobiology, Paris, France

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  • Anna Kicheva,

    Affiliation: Developmental Neurobiology, MRC-National Institute for Medical Research, London, United Kingdom

    X
  • Bennett G. Novitch,

    Affiliation: Department of Neurobiology, Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

    X
  • James Briscoe mail,

    james.briscoe@nimr.mrc.ac.uk

    Affiliation: Developmental Neurobiology, MRC-National Institute for Medical Research, London, United Kingdom

    X
  • Noriaki Sasai equal contributor

    equal contributor Contributed equally to this work with: Eric Dessaud, Noriaki Sasai

    Affiliation: Developmental Neurobiology, MRC-National Institute for Medical Research, London, United Kingdom

    X
  • Published: June 01, 2010
  • DOI: 10.1371/journal.pbio.1000382

About the Authors

Eric Dessaud, Vanessa Ribes, Nikolaos Balaskas, Anna Kicheva, James Briscoe, Noriaki Sasai
Developmental Neurobiology, MRC-National Institute for Medical Research, London, United Kingdom
Lin Lin Yang, Bennett G. Novitch
Department of Neurobiology, Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
Alessandra Pierani
Institut Jacques Monod, Université Paris Diderot, Program of Development and Neurobiology, Paris, France

Corresponding Author

Email: james.briscoe@nimr.mrc.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: ED VR JB NS. Performed the experiments: ED VR NB NS. Analyzed the data: AK. Contributed reagents/materials/analysis tools: LLY AP BN. Wrote the paper: ED VR JB NS.