Advertisement
Research Article

Discovery of Unique Lanthionine Synthetases Reveals New Mechanistic and Evolutionary Insights

  • Yuki Goto,

    Affiliation: Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

    X
  • Bo Li,

    Affiliation: Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

    X
  • Jan Claesen,

    Affiliation: Department of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom

    X
  • Yanxiang Shi,

    Affiliation: Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

    X
  • Mervyn J. Bibb,

    Affiliation: Department of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom

    X
  • Wilfred A. van der Donk mail

    vddonk@illinois.edu

    Affiliations: Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, The Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

    X
  • Published: March 23, 2010
  • DOI: 10.1371/journal.pbio.1000339

About the Authors

Yuki Goto, Yanxiang Shi, Wilfred A. van der Donk
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
Bo Li, Wilfred A. van der Donk
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
Jan Claesen, Mervyn J. Bibb
Department of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom
Wilfred A. van der Donk
The Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

Corresponding Author

Email: vddonk@illinois.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: YG BL JC MJB WAvdD. Performed the experiments: YG BL JC YS. Analyzed the data: YG BL JC YS MJB WAvdD. Contributed reagents/materials/analysis tools: YG BL JC. Wrote the paper: YG MJB WAvdD.