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Research Article

Sequestration of the Aβ Peptide Prevents Toxicity and Promotes Degradation In Vivo

  • Leila M. Luheshi equal contributor,

    equal contributor Contributed equally to this work with: Leila M. Luheshi, Wolfgang Hoyer

    Affiliation: Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

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  • Wolfgang Hoyer equal contributor,

    equal contributor Contributed equally to this work with: Leila M. Luheshi, Wolfgang Hoyer

    Affiliations: Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden, Institute of Physical Biology, Heinrich-Heine-University, Dusseldorf, Germany

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  • Teresa Pereira de Barros,

    Affiliation: Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

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  • Iris van Dijk Härd,

    Affiliation: Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden

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  • Ann-Christin Brorsson,

    Affiliation: Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

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  • Bertil Macao,

    Affiliation: Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden

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  • Cecilia Persson,

    Affiliation: The Swedish NMR Centre, University of Gothenburg, Gothenburg, Sweden

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  • Damian C. Crowther,

    Affiliations: Department of Genetics, University of Cambridge, Cambridge, United Kingdom, Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom

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  • David A. Lomas,

    Affiliation: Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom

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  • Stefan Ståhl,

    Affiliation: School of Biotechnology, AlbaNova University Center, Royal Institute of Technology (KTH), Stockholm, Sweden

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  • Christopher M. Dobson mail,

    cmd44@cam.ac.uk (CMD); torleif.hard@molbio.slu.se (TH)

    Affiliation: Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

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  • Torleif Härd mail

    cmd44@cam.ac.uk (CMD); torleif.hard@molbio.slu.se (TH)

    Affiliations: The Swedish NMR Centre, University of Gothenburg, Gothenburg, Sweden, Department of Molecular Biology, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden

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  • Published: March 16, 2010
  • DOI: 10.1371/journal.pbio.1000334

About the Authors

Leila M. Luheshi, Teresa Pereira de Barros, Ann-Christin Brorsson, Christopher M. Dobson
Department of Chemistry, University of Cambridge, Cambridge, United Kingdom
Wolfgang Hoyer, Iris van Dijk Härd, Bertil Macao
Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden
Wolfgang Hoyer
Institute of Physical Biology, Heinrich-Heine-University, Dusseldorf, Germany
Cecilia Persson, Torleif Härd
The Swedish NMR Centre, University of Gothenburg, Gothenburg, Sweden
Damian C. Crowther
Department of Genetics, University of Cambridge, Cambridge, United Kingdom
Damian C. Crowther, David A. Lomas
Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
Stefan Ståhl
School of Biotechnology, AlbaNova University Center, Royal Institute of Technology (KTH), Stockholm, Sweden
Torleif Härd
Department of Molecular Biology, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: LML WH IvDH CP DCC DAL CMD TH. Performed the experiments: LML WH TPdB ACB BM. Analyzed the data: LML WH TPdB IvDH TH. Contributed reagents/materials/analysis tools: DCC DAL SS. Wrote the paper: LML WH CMD TH.