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Research Article

Fumarase: A Mitochondrial Metabolic Enzyme and a Cytosolic/Nuclear Component of the DNA Damage Response

  • Ohad Yogev,

    Affiliation: Department of Microbiology and Molecular Genetics, IMRIC, Faculty of Medicine, Hebrew University, Jerusalem, Israel

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  • Orli Yogev,

    Affiliation: Department of Biochemistry and Molecular Biology, IMRIC, Faculty of Medicine, Hebrew University, Jerusalem, Israel

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  • Esti Singer,

    Affiliation: Department of Microbiology and Molecular Genetics, IMRIC, Faculty of Medicine, Hebrew University, Jerusalem, Israel

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  • Eitan Shaulian,

    Affiliation: Department of Biochemistry and Molecular Biology, IMRIC, Faculty of Medicine, Hebrew University, Jerusalem, Israel

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  • Michal Goldberg,

    Affiliation: Department of Genetics, The Institute of Life Sciences, The Hebrew University, Jerusalem, Israel

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  • Thomas D. Fox,

    Affiliation: Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

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  • Ophry Pines mail

    ophryp@ekmd.huji.ac.il

    Affiliation: Department of Microbiology and Molecular Genetics, IMRIC, Faculty of Medicine, Hebrew University, Jerusalem, Israel

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  • Published: March 09, 2010
  • DOI: 10.1371/journal.pbio.1000328

About the Authors

Ohad Yogev, Esti Singer, Ophry Pines
Department of Microbiology and Molecular Genetics, IMRIC, Faculty of Medicine, Hebrew University, Jerusalem, Israel
Orli Yogev, Eitan Shaulian
Department of Biochemistry and Molecular Biology, IMRIC, Faculty of Medicine, Hebrew University, Jerusalem, Israel
Michal Goldberg
Department of Genetics, The Institute of Life Sciences, The Hebrew University, Jerusalem, Israel
Thomas D. Fox
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

Corresponding Author

Email: ophryp@ekmd.huji.ac.il

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: Ohad Yogev, Orli Yogev, Eitan Shaulian, Michal Goldberg, Thomas D. Fox, Ophry Pines. Performed the experiments: Ohad Yogev, Orli Yogev, Esti Singer, Thomas D. Fox. Analyzed the data: Ohad Yogev, Orli Yogev, Eitan Shaulian, Michal Goldberg, Thomas D. Fox, Ophry Pines. Contributed reagents/materials/analysis tools: Michal Goldberg, Thomas D. Fox, Ophry Pines. Wrote the paper: Ohad Yogev, Michal Goldberg, Ophry Pines.