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Research Article

mRNA Secondary Structures Fold Sequentially But Exchange Rapidly In Vivo

  • Elisabeth M. Mahen,

    Affiliations: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America

    Current address: Lillehei Heart Institute and Pediatric Hematology, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Peter Y. Watson,

    Affiliations: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America

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  • Joseph W. Cottrell,

    Affiliations: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America

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  • Martha J. Fedor mail

    mfedor@scripps.edu

    Affiliations: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America

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  • Published: February 09, 2010
  • DOI: 10.1371/journal.pbio.1000307

About the Authors

Elisabeth M. Mahen, Peter Y. Watson, Joseph W. Cottrell, Martha J. Fedor
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
Elisabeth M. Mahen, Peter Y. Watson, Joseph W. Cottrell, Martha J. Fedor
The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America
Peter Y. Watson, Joseph W. Cottrell, Martha J. Fedor
Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America

Corresponding Author

Email: mfedor@scripps.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: EMM PYW MJF. Performed the experiments: EMM PYW JWC. Analyzed the data: EMM PYW JWC MJF. Wrote the paper: EMM MJF. Prepared figures: EMM PYW MJF.