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Research Article

CDC5 Inhibits the Hyperphosphorylation of the Checkpoint Kinase Rad53, Leading to Checkpoint Adaptation

  • Genevieve M. Vidanes,

    Affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

    Current address: Conway Institute, University College Dublin, Belfield, Dublin, Ireland

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  • Frédéric D. Sweeney,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

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  • Sarah Galicia,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

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  • Stephanie Cheung,

    Affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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  • John P. Doyle,

    Affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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  • Daniel Durocher,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

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  • David P. Toczyski mail

    toczyski@cc.ucsf.edu

    Affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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  • Published: January 26, 2010
  • DOI: 10.1371/journal.pbio.1000286

About the Authors

Genevieve M. Vidanes, Stephanie Cheung, John P. Doyle, David P. Toczyski
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
Frédéric D. Sweeney, Sarah Galicia, Daniel Durocher
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

Corresponding Author

Email: toczyski@cc.ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: GMV FDS DD DPT. Performed the experiments: GMV FDS SG SC JPD DPT. Analyzed the data: GMV FDS DD DPT. Contributed reagents/materials/analysis tools: GMV FDS DD DPT. Wrote the paper: GMV DPT.