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Research Article

A Conserved CXXC Motif in CD3ε Is Critical for T Cell Development and TCR Signaling

  • Yibing Wang,

    Affiliations: Integrated Department of Immunology, National Jewish Health, Denver, Colorado, United States of America, Howard Hughes Medical Institute, National Jewish Health, Denver, Colorado, United States of America

    Current address: Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America

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  • Dean Becker,

    Affiliations: Integrated Department of Immunology, National Jewish Health, Denver, Colorado, United States of America, Howard Hughes Medical Institute, National Jewish Health, Denver, Colorado, United States of America

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  • Tibor Vass,

    Affiliations: Integrated Department of Immunology, National Jewish Health, Denver, Colorado, United States of America, Howard Hughes Medical Institute, National Jewish Health, Denver, Colorado, United States of America

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  • Janice White,

    Affiliations: Integrated Department of Immunology, National Jewish Health, Denver, Colorado, United States of America, Howard Hughes Medical Institute, National Jewish Health, Denver, Colorado, United States of America

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  • Philippa Marrack,

    Affiliations: Integrated Department of Immunology, National Jewish Health, Denver, Colorado, United States of America, Howard Hughes Medical Institute, National Jewish Health, Denver, Colorado, United States of America, Department of Biochemistry and Molecular Genetics, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado, United States of America

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  • John W. Kappler mail

    kapplerj@njhealth.org

    Affiliations: Integrated Department of Immunology, National Jewish Health, Denver, Colorado, United States of America, Howard Hughes Medical Institute, National Jewish Health, Denver, Colorado, United States of America, Program in Biomolecular Structure, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado, United States of America

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  • Published: December 01, 2009
  • DOI: 10.1371/journal.pbio.1000253

About the Authors

Yibing Wang, Dean Becker, Tibor Vass, Janice White, Philippa Marrack, John W. Kappler
Integrated Department of Immunology, National Jewish Health, Denver, Colorado, United States of America
Yibing Wang, Dean Becker, Tibor Vass, Janice White, Philippa Marrack, John W. Kappler
Howard Hughes Medical Institute, National Jewish Health, Denver, Colorado, United States of America
Philippa Marrack
Department of Biochemistry and Molecular Genetics, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado, United States of America
John W. Kappler
Program in Biomolecular Structure, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado, United States of America

Corresponding Author

Email: kapplerj@njhealth.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: YW. Performed the experiments: YW. Analyzed the data: YW JWK. Contributed reagents/materials/analysis tools: YW DB TV JW. Wrote the paper: YW PM JWK.