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Research Article

β1 Integrin Maintains Integrity of the Embryonic Neocortical Stem Cell Niche

  • Karine Loulier equal contributor,

    equal contributor Contributed equally to this work with: Karine Loulier, Justin D. Lathia, Tarik F. Haydar, Charles ffrench-Constant

    Affiliation: Center for Neuroscience, Children's National Medical Center, Washington, D.C., United States of America

    X
  • Justin D. Lathia equal contributor,

    equal contributor Contributed equally to this work with: Karine Loulier, Justin D. Lathia, Tarik F. Haydar, Charles ffrench-Constant

    Affiliations: Department of Pathology, University of Cambridge, Cambridge, United Kingdom, Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom, Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom, Laboratory of Neuroscience, National Institute on Aging Intramural Research Program, Baltimore, Maryland, United States of America

    X
  • Veronique Marthiens,

    Affiliations: Department of Pathology, University of Cambridge, Cambridge, United Kingdom, Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom

    X
  • Jenne Relucio,

    Affiliation: Department of Pharmacology, State University of New York at Stony Brook, Stony Brook, New York, United States of America

    X
  • Mohamed R. Mughal,

    Affiliation: Laboratory of Neuroscience, National Institute on Aging Intramural Research Program, Baltimore, Maryland, United States of America

    X
  • Sung-Chun Tang,

    Affiliation: Laboratory of Neuroscience, National Institute on Aging Intramural Research Program, Baltimore, Maryland, United States of America

    X
  • Turhan Coksaygan,

    Affiliation: School of Medicine, University of Maryland, Baltimore, Maryland, United States of America

    X
  • Peter E. Hall,

    Affiliations: Department of Pathology, University of Cambridge, Cambridge, United Kingdom, Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom, Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom

    X
  • Srinivasulu Chigurupati,

    Affiliation: Laboratory of Neuroscience, National Institute on Aging Intramural Research Program, Baltimore, Maryland, United States of America

    X
  • Bruce Patton,

    Affiliation: Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, Oregon, United States of America

    X
  • Holly Colognato,

    Affiliation: Department of Pharmacology, State University of New York at Stony Brook, Stony Brook, New York, United States of America

    X
  • Mahendra S. Rao,

    Affiliations: Corporate Research Laboratories, Invitrogen Corporation, Carlsbad, California, United States of America, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Mark P. Mattson,

    Affiliations: Laboratory of Neuroscience, National Institute on Aging Intramural Research Program, Baltimore, Maryland, United States of America, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Tarik F. Haydar equal contributor mail,

    equal contributor Contributed equally to this work with: Karine Loulier, Justin D. Lathia, Tarik F. Haydar, Charles ffrench-Constant

    thaydar@cnmcresearch.org (TFH); cffc@ed.ac.uk (Cf-C)

    Affiliation: Center for Neuroscience, Children's National Medical Center, Washington, D.C., United States of America

    X
  • Charles ffrench-Constant equal contributor mail

    equal contributor Contributed equally to this work with: Karine Loulier, Justin D. Lathia, Tarik F. Haydar, Charles ffrench-Constant

    thaydar@cnmcresearch.org (TFH); cffc@ed.ac.uk (Cf-C)

    Affiliation: Department of Pathology, University of Cambridge, Cambridge, United Kingdom

    Current address: MRC Centre for Regenerative Medicine and Centre for Multiple Sclerosis Research, University of Edinburgh, Queens Medical Research Institute, Edinburgh, United Kingdom

    X
  • Published: August 18, 2009
  • DOI: 10.1371/journal.pbio.1000176

About the Authors

Karine Loulier, Tarik F. Haydar
Center for Neuroscience, Children's National Medical Center, Washington, D.C., United States of America
Justin D. Lathia, Veronique Marthiens, Peter E. Hall, Charles ffrench-Constant
Department of Pathology, University of Cambridge, Cambridge, United Kingdom
Justin D. Lathia, Veronique Marthiens, Peter E. Hall
Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom
Justin D. Lathia, Peter E. Hall
Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
Justin D. Lathia, Mohamed R. Mughal, Sung-Chun Tang, Srinivasulu Chigurupati, Mark P. Mattson
Laboratory of Neuroscience, National Institute on Aging Intramural Research Program, Baltimore, Maryland, United States of America
Jenne Relucio, Holly Colognato
Department of Pharmacology, State University of New York at Stony Brook, Stony Brook, New York, United States of America
Turhan Coksaygan
School of Medicine, University of Maryland, Baltimore, Maryland, United States of America
Bruce Patton
Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, Oregon, United States of America
Mahendra S. Rao
Corporate Research Laboratories, Invitrogen Corporation, Carlsbad, California, United States of America
Mahendra S. Rao, Mark P. Mattson
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: KL JDL HC MSR MPM TFH CfC. Performed the experiments: KL JDL VM TFH. Analyzed the data: KL JDL VM TFH CfC. Contributed reagents/materials/analysis tools: JR MRM SCT TC PEH SC BP HC. Wrote the paper: KL JDL TFH CfC.