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Research Article

Inherent Dynamics of the Acid-Sensing Ion Channel 1 Correlates with the Gating Mechanism

  • Huaiyu Yang equal contributor,

    equal contributor Contributed equally to this work with: Huaiyu Yang, Ye Yu

    Affiliation: Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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  • Ye Yu equal contributor,

    equal contributor Contributed equally to this work with: Huaiyu Yang, Ye Yu

    Affiliation: Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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  • Wei-Guang Li,

    Affiliation: Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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  • Fang Yu,

    Affiliation: Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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  • Hui Cao,

    Affiliation: Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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  • Tian-Le Xu mail,

    tlxu@ion.ac.cn (T-LX); hljiang@mail.shcnc.ac.cn (HJ)

    Affiliation: Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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  • Hualiang Jiang mail

    tlxu@ion.ac.cn (T-LX); hljiang@mail.shcnc.ac.cn (HJ)

    Affiliations: Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, School of Pharmacy, East China University of Science and Technology, Shanghai, China

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  • Published: July 14, 2009
  • DOI: 10.1371/journal.pbio.1000151

About the Authors

Huaiyu Yang, Hualiang Jiang
Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Ye Yu, Wei-Guang Li, Fang Yu, Hui Cao, Tian-Le Xu
Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
Hualiang Jiang
School of Pharmacy, East China University of Science and Technology, Shanghai, China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: HY YY TLX HJ. Performed the experiments: HY YY WGL FY HC. Analyzed the data: HY YY TLX HJ. Wrote the paper: HY YY TLX HJ.