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Research Article

Eps8 Regulates Axonal Filopodia in Hippocampal Neurons in Response to Brain-Derived Neurotrophic Factor (BDNF)

  • Elisabetta Menna equal contributor,

    equal contributor Contributed equally to this work with: Elisabetta Menna, Andrea Disanza

    Affiliations: Department of Medical Pharmacology, National Research Council (CNR) Institute of Neuroscience, University of Milan, Milan, Italy, Filarete Foundation, Milan, Italy

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  • Andrea Disanza equal contributor,

    equal contributor Contributed equally to this work with: Elisabetta Menna, Andrea Disanza

    Affiliation: IFOM Foundation – FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Itlay

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  • Cinzia Cagnoli,

    Affiliation: Department of Medical Pharmacology, National Research Council (CNR) Institute of Neuroscience, University of Milan, Milan, Italy

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  • Ursula Schenk,

    Affiliation: Department of Medical Pharmacology, National Research Council (CNR) Institute of Neuroscience, University of Milan, Milan, Italy

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  • Giuliana Gelsomino,

    Affiliation: Department of Medical Pharmacology, National Research Council (CNR) Institute of Neuroscience, University of Milan, Milan, Italy

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  • Emanuela Frittoli,

    Affiliation: IFOM Foundation – FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Itlay

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  • Maud Hertzog,

    Affiliation: IFOM Foundation – FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Itlay

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  • Nina Offenhauser,

    Affiliation: IFOM Foundation – FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Itlay

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  • Corinna Sawallisch,

    Affiliation: Institut für Humangenetik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

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  • Hans-Jürgen Kreienkamp,

    Affiliation: Institut für Humangenetik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

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  • Frank B. Gertler,

    Affiliation: Massachusetts Institute of Technology, Koch Institute, Cambridge, Massachusetts, United States of America

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  • Pier Paolo Di Fiore,

    Affiliations: IFOM Foundation – FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Itlay, Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy, University of Milan Medical School, Milan, Italy

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  • Giorgio Scita mail,

    Giorgio.scita@ifom-ieo-campus.it (GS); michela.matteoli@unimi.it (MM)

    Affiliations: IFOM Foundation – FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Itlay, University of Milan Medical School, Milan, Italy

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  • Michela Matteoli mail

    Giorgio.scita@ifom-ieo-campus.it (GS); michela.matteoli@unimi.it (MM)

    Affiliations: Department of Medical Pharmacology, National Research Council (CNR) Institute of Neuroscience, University of Milan, Milan, Italy, Filarete Foundation, Milan, Italy, Institute for Hospitalisation and Scientific Care (IRCCS) Don Gnocchi, Milan, Italy

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  • Published: June 30, 2009
  • DOI: 10.1371/journal.pbio.1000138

About the Authors

Elisabetta Menna, Cinzia Cagnoli, Ursula Schenk, Giuliana Gelsomino, Michela Matteoli
Department of Medical Pharmacology, National Research Council (CNR) Institute of Neuroscience, University of Milan, Milan, Italy
Elisabetta Menna, Michela Matteoli
Filarete Foundation, Milan, Italy
Andrea Disanza, Emanuela Frittoli, Maud Hertzog, Nina Offenhauser, Pier Paolo Di Fiore, Giorgio Scita
IFOM Foundation – FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Itlay
Corinna Sawallisch, Hans-Jürgen Kreienkamp
Institut für Humangenetik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany
Frank B. Gertler
Massachusetts Institute of Technology, Koch Institute, Cambridge, Massachusetts, United States of America
Pier Paolo Di Fiore
Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy
Pier Paolo Di Fiore, Giorgio Scita
University of Milan Medical School, Milan, Italy
Michela Matteoli
Institute for Hospitalisation and Scientific Care (IRCCS) Don Gnocchi, Milan, Italy

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: EM AD GS MM. Performed the experiments: EM AD CC US GG EF MH CS. Analyzed the data: EM AD. Contributed reagents/materials/analysis tools: NO HJK FBG PPDF GS MM. Wrote the paper: EM AD GS MM.