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Research Article

Crystal Structure of a Yeast Aquaporin at 1.15 Å Reveals a Novel Gating Mechanism

  • Gerhard Fischer equal contributor,

    equal contributor Contributed equally to this work with: Gerhard Fischer, Urszula Kosinska-Eriksson

    Affiliation: Department of Chemistry, Biochemistry and Biophysics, University of Gothenburg, Göteborg, Sweden

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  • Urszula Kosinska-Eriksson equal contributor,

    equal contributor Contributed equally to this work with: Gerhard Fischer, Urszula Kosinska-Eriksson

    Affiliation: Department of Chemistry, Biochemistry and Biophysics, University of Gothenburg, Göteborg, Sweden

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  • Camilo Aponte-Santamaría,

    Affiliation: Computational Biomolecular Dynamics Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany

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  • Madelene Palmgren,

    Affiliation: Department of Cell and Molecular Biology, University of Gothenburg, Göteborg, Sweden

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  • Cecilia Geijer,

    Affiliation: Department of Cell and Molecular Biology, University of Gothenburg, Göteborg, Sweden

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  • Kristina Hedfalk,

    Affiliation: Department of Chemistry, Biochemistry and Biophysics, University of Gothenburg, Göteborg, Sweden

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  • Stefan Hohmann,

    Affiliation: Department of Cell and Molecular Biology, University of Gothenburg, Göteborg, Sweden

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  • Bert L. de Groot,

    Affiliation: Computational Biomolecular Dynamics Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany

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  • Richard Neutze mail,

    Richard.Neutze@chem.gu.se (RN); Karin.Lindkvist@gu.se (KL-P)

    Affiliation: Department of Chemistry, Biochemistry and Biophysics, University of Gothenburg, Göteborg, Sweden

    X
  • Karin Lindkvist-Petersson mail

    Richard.Neutze@chem.gu.se (RN); Karin.Lindkvist@gu.se (KL-P)

    Affiliation: Department of Cell and Molecular Biology, University of Gothenburg, Göteborg, Sweden

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  • Published: June 16, 2009
  • DOI: 10.1371/journal.pbio.1000130

About the Authors

Gerhard Fischer, Urszula Kosinska-Eriksson, Kristina Hedfalk, Richard Neutze
Department of Chemistry, Biochemistry and Biophysics, University of Gothenburg, Göteborg, Sweden
Camilo Aponte-Santamaría, Bert L. de Groot
Computational Biomolecular Dynamics Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany
Madelene Palmgren, Cecilia Geijer, Stefan Hohmann, Karin Lindkvist-Petersson
Department of Cell and Molecular Biology, University of Gothenburg, Göteborg, Sweden

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: GF UKE CAS MP CG KH BLdG KLP. Performed the experiments: GF UKE CAS MP CG KH KLP. Analyzed the data: GF UKE CAS MP CG BLdG RN KLP. Wrote the paper: GF UKE CAS MP CG SH BLdG RN KLP.