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Research Article

Direct Binding of pRb/E2F-2 to GATA-1 Regulates Maturation and Terminal Cell Division during Erythropoiesis

  • Zahra Kadri,

    Affiliations: CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses, France, UMR INSERM U.962, University Paris XI, CEA, Fontenay-aux-Roses, France, Département d'Hématologie, INSERM U567, CNRS UMR 8104, Institute Cochin and University Paris V René Descartes, Paris, France

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  • Ritsuko Shimizu,

    Affiliation: Department of Molecular and Developmental Biology, Center for TARA, ERATO Environmental Response Project, University of Tsukuba, Tsukuba, Japan

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  • Osamu Ohneda,

    Affiliation: Department of Molecular and Developmental Biology, Center for TARA, ERATO Environmental Response Project, University of Tsukuba, Tsukuba, Japan

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  • Leila Maouche-Chretien,

    Affiliations: CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses, France, UMR INSERM U.962, University Paris XI, CEA, Fontenay-aux-Roses, France, Département d'Hématologie, INSERM U567, CNRS UMR 8104, Institute Cochin and University Paris V René Descartes, Paris, France

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  • Sylvie Gisselbrecht,

    Affiliation: Département d'Hématologie, INSERM U567, CNRS UMR 8104, Institute Cochin and University Paris V René Descartes, Paris, France

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  • Masayuki Yamamoto,

    Affiliation: Department of Molecular and Developmental Biology, Center for TARA, ERATO Environmental Response Project, University of Tsukuba, Tsukuba, Japan

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  • Paul-Henri Romeo,

    Affiliation: Département d'Hématologie, INSERM U567, CNRS UMR 8104, Institute Cochin and University Paris V René Descartes, Paris, France

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  • Philippe Leboulch,

    Affiliations: CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses, France, UMR INSERM U.962, University Paris XI, CEA, Fontenay-aux-Roses, France, Genetics Division, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Stany Chretien mail

    stany.chretien@cea.fr

    Affiliations: CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses, France, UMR INSERM U.962, University Paris XI, CEA, Fontenay-aux-Roses, France, Département d'Hématologie, INSERM U567, CNRS UMR 8104, Institute Cochin and University Paris V René Descartes, Paris, France, Genetics Division, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: June 09, 2009
  • DOI: 10.1371/journal.pbio.1000123

About the Authors

Zahra Kadri, Leila Maouche-Chretien, Philippe Leboulch, Stany Chretien
CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses, France
Zahra Kadri, Leila Maouche-Chretien, Philippe Leboulch, Stany Chretien
UMR INSERM U.962, University Paris XI, CEA, Fontenay-aux-Roses, France
Zahra Kadri, Leila Maouche-Chretien, Sylvie Gisselbrecht, Paul-Henri Romeo, Stany Chretien
Département d'Hématologie, INSERM U567, CNRS UMR 8104, Institute Cochin and University Paris V René Descartes, Paris, France
Ritsuko Shimizu, Osamu Ohneda, Masayuki Yamamoto
Department of Molecular and Developmental Biology, Center for TARA, ERATO Environmental Response Project, University of Tsukuba, Tsukuba, Japan
Philippe Leboulch, Stany Chretien
Genetics Division, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: stany.chretien@cea.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: ZK RS OO MY SC. Performed the experiments: ZK RS OO SC. Analyzed the data: ZK LM-C SG MY P-HR PL SC. Wrote the paper: PL SC. Originator of the central hypothesis: SC.