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Research Article

Regulation of Mammary Stem/Progenitor Cells by PTEN/Akt/β-Catenin Signaling

  • Hasan Korkaya mail,

    hkorkaya@med.umich.edu

    Affiliation: Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Amanda Paulson,

    Affiliation: Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Emmanuelle Charafe-Jauffret,

    Affiliation: Laboratory of Molecular Oncology, Marseille Cancer Research Institute, UMR 599 Inserm/Institut Paoli – Calmettes, Marseille, France

    X
  • Christophe Ginestier,

    Affiliation: Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Marty Brown,

    Affiliation: Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Julie Dutcher,

    Affiliation: Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Shawn G. Clouthier,

    Affiliation: Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Max S. Wicha

    Affiliation: Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Published: June 02, 2009
  • DOI: 10.1371/journal.pbio.1000121

About the Authors

Hasan Korkaya, Amanda Paulson, Christophe Ginestier, Marty Brown, Julie Dutcher, Shawn G. Clouthier, Max S. Wicha
Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
Emmanuelle Charafe-Jauffret
Laboratory of Molecular Oncology, Marseille Cancer Research Institute, UMR 599 Inserm/Institut Paoli – Calmettes, Marseille, France

Corresponding Author

Email: hkorkaya@med.umich.edu

Competing Interests

MSW holds equity in and is a scientific consultant for OncoMed Pharmaceuticals.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: HK MW. Performed the experiments: HK AP MB JD. Analyzed the data: HK MW. Contributed reagents/materials/analysis tools: ECJ CG SGC. Wrote the paper: HK MW.