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Research Article

Polo-Like Kinase 1 Directs Assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF Complex to Initiate Cleavage Furrow Formation

  • Benjamin A. Wolfe,

    Affiliation: Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois, United States of America

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  • Tohru Takaki,

    Affiliation: Cell Division and Aneuploidy Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, Hertfordshire, United Kingdom

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  • Mark Petronczki,

    Affiliation: Cell Division and Aneuploidy Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, Hertfordshire, United Kingdom

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  • Michael Glotzer mail

    mglotzer@uchicago.edu

    Affiliation: Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois, United States of America

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  • Published: May 26, 2009
  • DOI: 10.1371/journal.pbio.1000110

About the Authors

Benjamin A. Wolfe, Michael Glotzer
Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois, United States of America
Tohru Takaki, Mark Petronczki
Cell Division and Aneuploidy Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, Hertfordshire, United Kingdom

Corresponding Author

Email: mglotzer@uchicago.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: BAW TT MP MG. Performed the experiments: BAW TT MP. Analyzed the data: BAW TT MP MG. Wrote the paper: BAW MP MG.