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Research Article

Direct Observation of ATP-Induced Conformational Changes in Single P2X4 Receptors

  • Youichi Shinozaki mail,

    To whom correspondence should be addressed. E-mail: shinozak@will.brl.ntt.co.jp

    Affiliation: NTT Basic Research Laboratories, NTT Corporation, Kanagawa, Japan

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  • Koji Sumitomo,

    Affiliation: NTT Basic Research Laboratories, NTT Corporation, Kanagawa, Japan

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  • Makoto Tsuda,

    Affiliation: Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan

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  • Schuichi Koizumi,

    Affiliation: Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan

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  • Kazuhide Inoue,

    Affiliation: Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan

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  • Keiichi Torimitsu

    Affiliation: NTT Basic Research Laboratories, NTT Corporation, Kanagawa, Japan

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  • Published: May 05, 2009
  • DOI: 10.1371/journal.pbio.1000103

About the Authors

Youichi Shinozaki, Koji Sumitomo, Keiichi Torimitsu
NTT Basic Research Laboratories, NTT Corporation, Kanagawa, Japan
Makoto Tsuda, Kazuhide Inoue
Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
Schuichi Koizumi
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan

Corresponding Author

Email: shinozak@will.brl.ntt.co.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

YS, KS, MT, SK, KI, and KT conceived and designed the experiments. YS and KS performed the experiments. YS, KS, MT, SK, KI, and KT analyzed the data. YS, MT, and SK contributed reagents/materials/analysis tools. YS wrote the paper.