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Research Article

Evolution of Complex RNA Polymerases: The Complete Archaeal RNA Polymerase Structure

  • Yakov Korkhin,

    Affiliations: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, Howard Hughes Medical Institute, Yale University, New Haven, Connecticut, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Harvard University, Boston, Massachusetts, United States of America

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  • Ulug M Unligil,

    Affiliations: Harvard Medical School, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Harvard University, Boston, Massachusetts, United States of America

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  • Otis Littlefield,

    Affiliations: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, Howard Hughes Medical Institute, Yale University, New Haven, Connecticut, United States of America

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  • Pamlea J Nelson,

    Affiliations: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, Howard Hughes Medical Institute, Yale University, New Haven, Connecticut, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Harvard University, Boston, Massachusetts, United States of America

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  • David I Stuart,

    Affiliation: Division of Structural Biology and the Oxford Protein Production Facility, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Paul B Sigler †,

    † Deceased.

    Affiliations: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, Howard Hughes Medical Institute, Yale University, New Haven, Connecticut, United States of America

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  • Stephen D Bell,

    Affiliation: Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

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  • Nicola G. A Abrescia mail

    To whom correspondence should be addressed. E-mail: nabrescia@cicbiogune.es

    Affiliations: Division of Structural Biology and the Oxford Protein Production Facility, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Structural Biology Unit, CIC bioGUNE, Derio, Spain

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  • Published: May 05, 2009
  • DOI: 10.1371/journal.pbio.1000102

About the Authors

Yakov Korkhin, Otis Littlefield, Pamlea J Nelson, Paul B Sigler
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America
Yakov Korkhin, Otis Littlefield, Pamlea J Nelson, Paul B Sigler
Howard Hughes Medical Institute, Yale University, New Haven, Connecticut, United States of America
Yakov Korkhin, Ulug M Unligil, Pamlea J Nelson
Harvard Medical School, Boston, Massachusetts, United States of America
Yakov Korkhin, Ulug M Unligil, Pamlea J Nelson
Howard Hughes Medical Institute, Harvard University, Boston, Massachusetts, United States of America
David I Stuart, Nicola G. A Abrescia
Division of Structural Biology and the Oxford Protein Production Facility, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Stephen D Bell
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
Nicola G. A Abrescia
Structural Biology Unit, CIC bioGUNE, Derio, Spain

Corresponding Author

Email: nabrescia@cicbiogune.es

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

YK, PBS, SDB, and NGAA conceived and designed the experiments. YK, UMU, OL, PJN, SDB, and NGAA performed the experiments. YK, PBS, DIS, SDB, and NGAA analyzed the data. DIS, SDB, and NGAA wrote the paper.