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Research Article

Impaired Antibody Response Causes Persistence of Prototypic T Cell–Contained Virus

  • Andreas Bergthaler mail,

    To whom correspondence should be addressed. E-mail: andreas.bergthaler@gmail.com (AB); daniel.pinschewer@gmx.ch (DDP)

    Affiliations: Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland, Institute for Clinical Pathology, University Hospital of Zurich, Zurich, Switzerland

    ¤a Current address: Institute for Systems Biology, Seattle, Washington, United States of America

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  • Lukas Flatz equal contributor,

    equal contributor Contributed equally to this work with: Lukas Flatz, Admar Verschoor

    Affiliations: Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland, Institute for Clinical Pathology, University Hospital of Zurich, Zurich, Switzerland

    ¤b Current address: Vaccine Research Center, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Admar Verschoor equal contributor,

    equal contributor Contributed equally to this work with: Lukas Flatz, Admar Verschoor

    Affiliation: Institute for Clinical Pathology, University Hospital of Zurich, Zurich, Switzerland

    ¤b Current address: Vaccine Research Center, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Ahmed N Hegazy,

    Affiliation: Institute for Clinical Pathology, University Hospital of Zurich, Zurich, Switzerland

    ¤d Current address: German Rheumatism Research Center Berlin, Berlin, Germany

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  • Martin Holdener,

    Affiliation: Institute for Clinical Pathology, University Hospital of Zurich, Zurich, Switzerland

    ¤e Current address: Pharmacenter, Johann Wolfgang Goethe University, Frankfurt am Main, Germany

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  • Katja Fink,

    Affiliation: Institute for Clinical Pathology, University Hospital of Zurich, Zurich, Switzerland

    ¤f Current address: Novartis Institute for Tropical Diseases, Singapore, Singapore

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  • Bruno Eschli,

    Affiliation: Institute for Clinical Pathology, University Hospital of Zurich, Zurich, Switzerland

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  • Doron Merkler,

    Affiliation: Department of Neuropathology, Georg-August-University Goettingen, Goettingen, Germany

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  • Rami Sommerstein,

    Affiliations: Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland, WHO Collaborating Centre for Neonatal Vaccinology, University of Geneva, Geneva, Switzerland

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  • Edit Horvath,

    Affiliation: Institute for Clinical Pathology, University Hospital of Zurich, Zurich, Switzerland

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  • Marylise Fernandez,

    Affiliations: Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland, WHO Collaborating Centre for Neonatal Vaccinology, University of Geneva, Geneva, Switzerland

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  • André Fitsche,

    Affiliation: Institute for Clinical Pathology, University Hospital of Zurich, Zurich, Switzerland

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  • Beatrice M Senn,

    Affiliation: Institute for Clinical Pathology, University Hospital of Zurich, Zurich, Switzerland

    ¤g Current address: Intercell AG, Vienna, Austria

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  • J. Sjef Verbeek,

    Affiliation: Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands

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  • Bernhard Odermatt,

    Affiliation: Institute for Clinical Pathology, University Hospital of Zurich, Zurich, Switzerland

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  • Claire-Anne Siegrist,

    Affiliations: Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland, WHO Collaborating Centre for Neonatal Vaccinology, University of Geneva, Geneva, Switzerland, Department of Pediatrics, University of Geneva, Geneva, Switzerland

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  • Daniel D Pinschewer mail

    To whom correspondence should be addressed. E-mail: andreas.bergthaler@gmail.com (AB); daniel.pinschewer@gmx.ch (DDP)

    Affiliations: Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland, Institute for Clinical Pathology, University Hospital of Zurich, Zurich, Switzerland, WHO Collaborating Centre for Neonatal Vaccinology, University of Geneva, Geneva, Switzerland

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  • Published: April 07, 2009
  • DOI: 10.1371/journal.pbio.1000080

About the Authors

Andreas Bergthaler, Lukas Flatz, Rami Sommerstein, Marylise Fernandez, Claire-Anne Siegrist, Daniel D Pinschewer
Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
Andreas Bergthaler, Lukas Flatz, Admar Verschoor, Ahmed N Hegazy, Martin Holdener, Katja Fink, Bruno Eschli, Edit Horvath, André Fitsche, Beatrice M Senn, Bernhard Odermatt, Daniel D Pinschewer
Institute for Clinical Pathology, University Hospital of Zurich, Zurich, Switzerland
Doron Merkler
Department of Neuropathology, Georg-August-University Goettingen, Goettingen, Germany
Rami Sommerstein, Marylise Fernandez, Claire-Anne Siegrist, Daniel D Pinschewer
WHO Collaborating Centre for Neonatal Vaccinology, University of Geneva, Geneva, Switzerland
J. Sjef Verbeek
Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
Claire-Anne Siegrist
Department of Pediatrics, University of Geneva, Geneva, Switzerland

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AB, AV, ANH, MH, KF, C-AS, and DDP conceived and designed the experiments. AB, LF, AV, ANH, MH, KF, RS, EH, MF, AF, and DDP performed the experiments. AB, LF, AV, ANH, MH, KF, DM, RS, BO, C-AS, and DDP analyzed the data. BE, BMS, and JSV contributed reagents/materials/analysis tools. AB, AV, and DDP wrote the paper.