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Research Article

Oncogenic Kras Initiates Leukemia in Hematopoietic Stem Cells

  • Amit J Sabnis,

    Affiliation: Department of Pediatrics, University of California San Francisco, San Francisco, California, United States of America

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  • Laurene S Cheung,

    Affiliation: Department of Pediatrics, University of California San Francisco, San Francisco, California, United States of America

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  • Monique Dail,

    Affiliation: Department of Pediatrics, University of California San Francisco, San Francisco, California, United States of America

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  • Hio Chung Kang,

    Affiliation: Department of Pediatrics, University of California San Francisco, San Francisco, California, United States of America

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  • Marianne Santaguida,

    Affiliation: The Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, California, United States of America

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  • Michelle L Hermiston,

    Affiliation: Department of Pediatrics, University of California San Francisco, San Francisco, California, United States of America

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  • Emmanuelle Passegué,

    Affiliation: The Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, California, United States of America

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  • Kevin Shannon,

    Affiliation: Department of Pediatrics, University of California San Francisco, San Francisco, California, United States of America

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  • Benjamin S Braun mail

    To whom correspondence should be addressed. E-mail: braunb@peds.ucsf.edu

    Affiliation: Department of Pediatrics, University of California San Francisco, San Francisco, California, United States of America

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  • Published: March 17, 2009
  • DOI: 10.1371/journal.pbio.1000059

About the Authors

Amit J Sabnis, Laurene S Cheung, Monique Dail, Hio Chung Kang, Michelle L Hermiston, Kevin Shannon, Benjamin S Braun
Department of Pediatrics, University of California San Francisco, San Francisco, California, United States of America
Marianne Santaguida, Emmanuelle Passegué
The Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: braunb@peds.ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AJS, LSC, MD, HCK, MS, MLH, EP, KS, and BSB conceived and designed the experiments. AJS, LSC, MD, HCK, MLH, and BSB performed the experiments. AJS, LSC, MD, HCK, MS, MLH, KS, and BSB analyzed the data. MD, HCK, MS, MLH, EP, KS, and BSB contributed reagents/materials/analysis tools. AJS, KS, and BSB wrote the paper.